Table 6.

Multivariate Cox regression models showing the risk of ACGL, DCGL, and DWFG in recipients of kidney transplant from a DCD donor with increasing total donor WIT compared with NBD donor kidney transplant recipients

FactorHR (95% CI)
ACGLDCGLDWFG
NBD1.001.001.00
DCD WIT, min0.96 (0.90 to 1.02)0.91 (0.83 to 1.00)1.01 (0.89 to 1.07)
 10–260.96 (0.88 to 1.05)0.97 (0.85 to 1.09)0.94 (0.82 to 1.07)
 27–341.09 (0.98 to 1.23)1.05 (0.90 to 1.24)1.14 (0.97 to 1.35)
 35–481.23 (1.07 to 1.41)1.07 (0.87 to 1.31)1.39 (1.15 to 1.68)
 >48
Recipient age, yr
 18–391.001.001.00
 40–590.97 (0.92 to 1.02)0.65 (0.62 to 0.69)2.25 (2.04 to 2.48)
 ≥601.41 (1.34 to 1.49)0.71 (0.66 to 0.76)4.15 (3.76 to 4.59)
Recipient: woman0.91 (0.88 to 0.94)0.97 (0.92 to 1.01)0.86 (0.82 to 0.91)
Recipient race
 White1.001.001.00
 Black1.03 (0.99 to 1.07)1.39 (1.31 to 1.46)0.75 (0.70 to 0.79)
 Other0.69 (0.66 to 0.73)0.86 (0.81 to 0.92)0.57 (0.53 to 0.60)
Cause of ESRD
 Diabetes1.37 (1.32 to 1.42)0.98 (0.93 to 1.04)1.82 (1.73 to 1.91)
Dialysis exposure, yr
 ≤11.001.001.00
 1.1–31.24 (1.17 to 1.31)1.16 (1.08 to 1.24)1.32 (1.22 to 1.43)
 3.1–51.39 (1.32 to 1.47)1.19 (1.10 to 1.28)1.63 (1.50 to 1.76)
 >51.67 (1.58 to 1.77)1.27 (1.18 to 1.38)2.22 (2.05 to 2.40)
Peak PRA
 01.001.001.00
 1–301.05 (1.01 to 1.10)1.03 (0.98 to 1.10)1.07 (1.01 to 1.13)
 31–801.08 (1.03 to 1.14)1.10 (1.03 to 1.18)1.06 (0.99 to 1.14)
 >801.24 (1.17 to 1.31)1.28 (1.19 to 1.38)1.20 (1.12 to 1.31)
KDPI quartile, %
 0–251.001.001.00
 26–501.16 (1.10 to 1.21)1.13 (1.04 to 1.19)1.20 (1.11 to 1.29)
 51–751.49 (1.42 to 1.56)1.45 (1.35 to 1.55)1.52 (1.42 to 1.64)
 76–1001.98 (1.88 to 2.08)2.22 (2.06 to 2.38)1.78 (1.65 to 1.91)
HLA MM
 01.001.001.00
 1–31.00 (0.93 to 1.08)1.10 (0.99 to 1.22)0.93 (0.84 to 1.03)
 4–51.04 (0.97 to 1.11)1.20 (1.09 to 1.32)0.91 (0.84 to 1.00)
 61.09 (1.01 to 1.17)1.29 (1.16 to 1.44)0.93 (0.84 to 1.03)
Induction
 None1.06 (1.00 to 1.11)1.06 (0.98 to 1.13)1.05 (0.98 to 1.13)
 Nondepleting1.02 (0.98 to 1.07)1.00 (0.94 to 1.07)1.04 (0.98 to 1.11)
 Depleting1.001.001.00
CIT, h
 ≤121.001.001.00
 13–241.10 (1.06 to 1.14)1.08 (1.02 to 1.14)1.11 (1.05 to 1.18)
 >241.14 (1.09 to 1.20)1.11 (1.04 to 1.19)1.18 (1.09 to 1.26)
Machine perfusion1.02 (0.99 to 1.06)1.04 (0.99 to 1.10)1.00 (0.95 to 1.06)
  • HR, hazard ratio; 95% CI, 95% confidence interval; PRA, panel reactive antibody; MM, mismatch.