Table 1.

Patient demographics and baseline characteristics

CharacteristicMultitarget, n=116AZA, n=90Total, n=206
Sex, women/men108/881/9189/17
Age, yr30.0 (24.0, 38.0)33.0 (26.0, 40.0)32.0 (24.0, 39.0)
Pathologic classification, n (%)
 Class III5 (4.3)7 (7.8)12 (5.8)
 Class IV50 (43.1)39 (43.3)89 (43.2)
 Class V14 (12.1)12 (13.3)26 (12.6)
 Class III+V15 (12.9)2 (2.2)17 (8.3)
 Class IV+V32 (27.6)30 (33.3)62 (30.1)
Remission condition (%)a
 CR69 (59.5)40 (44.4)109 (52.9)
 PR47 (40.5)50 (55.6)97 (47.1)
SLEDAIa4.0 (2.0, 4.5)4.0 (2.0, 6.0)4.0 (2.0, 6.0)
Urinary protein, g/24 ha0.35 (0.16, 0.63)0.49 (0.17, 0.90)0.38 (0.17, 0.77)
Serum albumin, g/L43.4±4.142.4±4.242.9±4.1
SCr, μmol/L61.9 (54.9, 74.4)61.0 (54.0, 74.3)61.4 (54.8, 74.3)
eGFR, ml/min per 1.73 m2, n (%)
 ≥9094 (81.0)72 (80.0)166 (80.6)
 ≥60 to <9018 (15.5)15 (16.7)33 (16.0)
 ≥30 to <603 (2.6)3 (3.3)6 (2.9)
 <301 (0.9)0 (0)1 (0.5)
Serum C3, mg/dl85.05 (74.20, 105.00)80.70 (69.60, 94.60)82.00 (72.20, 100.00)
Serum C4, mg/dl16.55 (12.20, 21.30)15.60 (12.00, 19.30)16.00 (12.10, 20.95)
Hemoglobin, g/L118.0 (110.5, 126.5)121.5 (112.0, 130.0)119.0 (111.0, 128.0)
Anti-dsDNA positive rate, n (%)29/115 (25.2)24/83 (28.9)53/198 (26.8)
Renal tubular function
 NAG, U/g creatinine5.53 (3.50, 9.80)4.80 (4.19, 5.81)5.30 (3.50, 9.60)
 RBP, mg/L0.35 (0.20, 0.50)0.53 (0.42, 0.80)0.40 (0.20, 0.72)
  • Data are expressed as numbers (%), medians (25th, 75th percentiles), or means (SD). Reference ranges were as follows: urinary protein, ≤0.4 g/24 h; serum albumin, 35–55 g/L; SCr, men: 45–110 μmol/L (0.51–1.24 mg/dl) and women: 45–93 μmol/L (0.51–1.05 mg/dl); eGFR, 90–120 ml/min per 1.73 m2; hemoglobin, 130–175 g/L (men) and 115–150 g/L (women); serum C3, 80–180 mg/dl; serum C4, 10–40 mg/dl; NAG, ≤16.5 U/g creatinine; RBP, ≤0.5 mg/L. Anti-dsDNA, antidouble-stranded DNA.

  • a P<0.05.