Table 7.

Adjusted HRs of death, discontinued dialysis, and hospitalization associated with specific opioid prescription in 2010 prevalent dialysis cohort

Specific OpioidNOutcome: DeathOutcome: Discontinued DialysisOutcome: Hospitalization
HR95% CIP ValueHR95% CIP ValueHR95% CIP Value
 Chronicb18,0061.291.24 to 1.33<0.0011.361.22 to 1.52<0.0011.291.26 to 1.32<0.001
 Chronicb83571.331.27 to 1.39<0.0011.571.35 to 1.84<0.0011.401.36 to 1.44<0.001
 Chronicb21241.331.23 to 1.43<0.0011.471.17 to 1.850.0011.231.17 to 1.29<0.001
 Chronicb38761.181.11 to 1.26<0.0011.140.93 to 1.390.211.251.20 to 1.30<0.001
 Chronicb9761.131.001 to to 1.900.191.291.20 to 1.39<0.001
 Chronicb10251.561.40 to 1.74<0.0011.921.37 to 2.69<0.0011.541.44 to 1.65<0.001
 Chronicb8671.651.47 to 1.85<0.0012.581.83 to 3.64<0.0011.581.46 to 1.70<0.001
 Chronicb19261.391.29 to 1.50<0.0011.591.26 to 1.99<0.0011.311.24 to 1.38<0.001
  • Cox proportional hazards model adjusted for sex, race, age, year of ESRD, dialysis modality, analgesic prescriptions, history of kidney transplantation, dual status, residential area, nursing home residence, cancer, pain-related hospitalization in 2010, number of hospitalization in 2010, and comorbidities reported in CMS Form 2728 (chronic obstructive pulmonary disease, congestive heart failure, peripheral vascular disease, cerebrovascular disease, atherosclerotic heart disease, diabetes, AIDS, and smoking) in each model.

  • a A 0-day supply within the study year.

  • b A 90-day or more supply within the study year.