Table 2.

Sensitivity, specificity, PPV, and NPV with respect to eGFR and dialysis treatment status over 24 hours after presentation for hs-cTnI assay

Renal FunctionnSensitivity, %Specificity, %PPV, %NPV, %
Normal
 Baseline72275.5 (63.5 to 87.6)95.3 (93.6 to 96.9)53.6 (41.9 to 65.4)98.2 (97.1 to 99.2)
 3 h50191.2 (81.6 to 100.0)93.6 (91.4 to 95.8)50.8 (38.3 to 63.4)99.3 (98.6 to 100.0)
 6 h49994.3 (86.6 to 100.0)93.1 (90.8 to 95.4)50.8 (38.6 to 62.9)99.5 (98.9 to 100.0)
 9 h42194.3 (86.6 to 100.0)93.5 (91.1 to 96.0)56.9 (44.2 to 69.6)99.5 (98.7 to 100.0)
 0/3 h50194.1 (86.2 to 100.0)92.9 (90.6 to 95.3)49.2 (37.1 to 61.4)99.5 (98.9 to 100.0)
Mildly impaired
 Baseline44562.0 (48.6 to 75.5)87.6 (84.3 to 90.9)38.8 (28.1 to 49.4)94.8 (92.5 97.1)
 3 h28093.3 (84.4 to 100.0)86.4 (82.2 to 90.7)45.2 (32.8 to 57.6)99.1 (97.8 to 100.0)
 6 h29194.6 (87.3 to 100.0)83.5 (78.9 to 88.0)45.5 (34.3 to 56.6)99.1 (97.8 to 100.0)
 9 h25992.9 (85.1 to 100.0)86.7 (82.1 to 91.2)57.4 (45.6 to 69.1)98.4 (96.7 to 100.0)
 0/3 h28093.3 (84.4 to 100.0)86.0 (81.7 to 90.3)44.4 (32.2 to 56.7)99.1 (97.8 to 100.0)
Moderately impaired
 Baseline22951.2 (35.9 to 66.5)78.7 (72.9 to 84.6)34.4 (22.5 to 46.4)88.1 (83.2 to 93.0)
 3 h14796.4 (89.6 to 100.0)77.3 (69.8 to 84.8)50.0 (36.7 to 63.3)98.9 (96.8 to 100.0)
 6 h15187.1 (75.3 to 98.9)71.7 (63.6 to 79.7)44.3 (31.8 to 56.7)95.6 (91.3 to 99.8)
 9 h14996.9 (90.9 to 100.0)67.5 (59.0 to 76.0)44.9 (33.2 to 56.7)98.8 (96.3 to 100.0)
 0/3 h14796.4 (89.6 to 100.0)76.5 (68.9 to 84.1)49.1 (35.9 to 62.3)98.9 (96.8 to 100.0)
Severely impaired
 Baseline8194.1 (82.9 to 100.0)60.9 (49.0 to 72.9)39.0 (24.1 to 54.0)97.5 (92.7 to 100.0)
 3 h46100.0 (63.1 to 100.0)57.9 (42.2 to 73.6)33.3 (14.5 to 52.2)100.0 (84.6 to 100.0)
 6 h57100.0 (75.3 to 100.0)59.1 (44.6 to 73.6)41.9 (24.6 to 59.3)100.0 (86.8 100.0)
 9 h51100.0 (59.0 to 100.0)56.8 (42.2 to 71.5)26.9 (9.9 to 44.0)100.0 (86.3 to 100.0)
 0/3 h46100.0 (63.1 to 100.0)57.9 (42.2 to 73.6)33.3 (14.5 to 52.2)100.0 (84.6 to 100.0)
Dialysis
 Baseline7870.0 (41.6 to 98.4)39.7 (28.1 to 51.3)14.6 (4.6 to 24.6)90.0 (79.3 to 100.0)
 3 h4685.7 (59.8 to 100.0)41.0 (25.6 to 56.5)20.7 (6.0 to 35.4)94.1 (82.9 to 100.0)
 6 h57100.0 (63.1 to 100.0)40.8 (27.1 to 54.6)21.6 (8.4 to 34.9)100.0 (83.2 to 100.0)
 9 h4290.0 (71.4 to 100.0)40.6 (23.6 to 57.6)32.1 (14.8 to 49.4)92.9 (79.4 to 100.0)
 0/3 h46100.0 (59.0 to 100.0)41.0 (25.6 to 56.5)23.3 (8.2 to 38.5)100.0 (79.4 to 100.0)
  • The 95% CIs are shown in parentheses. Normal: eGFR≥90 ml/min per 1.73 m2; mildly impaired: eGFR≥60 to <90 ml/min per 1.73 m2; moderately impaired: eGFR≥30 to <60 ml/min per 1.73 m2; severely impaired: eGFR≤30 ml/min per 1.73 m2.