Table 2.

Prespecified end points

Primary end point
 Development of AKI within 7 d of surgery according to KDIGO criteria
Secondary end points
 Development of AKI within 7 d of surgery according to serum creatinine–based KDIGO criteria
 Severity of AKI per KDIGO criteria
 Duration of AKI within the first 7 d
 Death, dialysis, or eGFR decline >30% at day 30
Exploratory end points
 Serum creatinine over time and maximum change from baseline
 eGFR over time and maximum change from baseline
 AUC for serum creatinine and serum creatinine change from baseline through days 7 and 90
 AKI or death during the first 7 d
 Time to doubling of serum creatinine, dialysis, or death
 At least doubling of serum creatinine, dialysis, or death
 Death, dialysis, or eGFR decline >30% at day 30
 Time to dialysis or death
 Time to death of any cause
 Urine volume <0.5 ml/kg per hour for 6 h consecutively during the first 48 h
 Development of AKI within 7 d of surgery according to the RIFLE criteria
 Development of AKI within 7 d of surgery according to the AKIN criteria
 Time on dialysis through day 90
 Time in ICU, CCU, or step-down unit
 Time in hospital
 Readmission in hospital within 30 d of surgery
 Time to readmission to hospital
 Creatinine kinase MB isoenzyme fraction, troponin I, and troponin T over time
 Albumin-to-creatinine ratio, KIM-1–to-creatinine ratio, and NGAL-to-creatinine ratio over time
  • AKIN, Acute Kidney Injury Network; ICU, intensive care unit; CCU, cardiac care unit; KIM-1, kidney injury molecule-1; NGAL, neutrophil gelatinase–associated lipocalin.