Table 1.

Demographic and immunopathologic characteristics of the patients of the GEMRITUX cohort, according to therapeutic intervention at M0, M3, and M6

CharacteristicsWhole Cohort, n=58NIAT, n=29RITUX, n=29P Value
Age56.5 [42.0–63.0]59.0 [44.0–63.0]52.0 [41.0–63.0]0.5
Sex0.4
 Men42 (72.4)1923
 Women16 (27.6)106
Proteinuria at M0, g/g of serum creatinine8.2 [4.8–10.0]7.4 [6.2–9.0]8.4 [4.4–11.0]0.51
Serum albumin at M0, g/dl2.2 [1.9–2.5]2.2 [2.0–2.5]2.2 [1.8–2.5]0.52
Serum creatinine at M0, mg/L10.8 [9.0–13.8]10.4 [8.7–13.8]11.5 [9.4–13.1]0.48
PLA2R1-Ab at M0, RU/ml101.5 [31.2–481.2]199.5 [24.2–480.0]100.5 [35.4–481.2]0.85
CysR at M0, RU/ml1423.5 [369.0–3240.0]1572.0 [494.0–3240.0]1256.0 [270.0–3114.0]0.52
CTLD1 at M0, RU/ml157.0 [0.0–2334.0]12.0 [0.0–1190.0]471.0 [0.0–2334.0]0.33
CTLD7 at M0, RU/ml220.5 [23.0–609.0]136.0 [36.0–662.0]223.0 [13.0–604.0]0.65
Group M00.74
 CysR20 (34.48)11 (37.93)9 (31.03)
 CysRC18 (13.79)4 (13.79)4 (13.79)
 CysRC710 (17.24)6 (20.69)4 (13.79)
 CysRC1C720 (34.48)8 (27.59)12 (41.38)
Spreading M038/58 (65.6)18 (62.1)20 (68.9)0.78
Proteinuria at M3, g/g of serum creatininea5.1 [3.2–7.6]5.0 [3.0–8.5]5.1 [3.5–7.4]0.86
Serum albumin at M3, g/dlb2.6 [2.0–2.9]2.3 [1.8–2.7]2.7 [2.1–3.1]0.12
Serum creatinine at M3, mg/La11.5 [9.4–13.6]11.5 [9.7–13.9]11.8 [9.0–13.6]0.99
PLA2R1-Ab at M3, RU/mlc43.1 [0–102.5]70.5 [30.3–325.9]0.0 [0.0–60.5]0.002
Group M3d0.002
 Negative12 (24.5)0 (0.0)12 (46.2)
 CysR10 (20.4)7 (30.4)3 (11.5)
 CysRC19 (18.4)6 (26.1)3 (11.5)
 CysRC76 (12.2)3 (13.1)3 (11.5)
 CysRC1C712 (24.5)7 (30.4)5 (19.2)
Spreading M3d27/49 (55.1)16 (69.6)11 (42.3)0.09
Proteinuria at M6, g/g of serum creatininee4.4 [2.0–7.3]6.2 [2.2–7.5]3.7 [1.8–6.5]0.21
Serum albumin at M6, g/dle2.6 [2.1–3.3]2.4 [2.0–2.9]2.9 [2.5–3.4]0.07
Serum creatinine at M6, mg/Le11.9 [9.4–14.8]12.0 [9.4–14.4]11.9 [9.8–14.8]0.71
PLA2R1-Ab at M6, RU/mlf30.1 [0–98.5]57.2 [16.5–298.0]0 [0–57.0]0.01
Group M6c
 Negative17 (34.0)0 (0.0)17 (65.4)
 CysR14 (28.0)12 (50.0)2 (7.7)<0.001
 CysRC15(10.0)4 (16.7)1 (3.9)
 CysRC72 (4.0)2 (8.3)0 (0.0)
 CysRC1C712 (24.0)6 (25.0)6 (23.1)
Spreading M6c19/50 (38.0)12/24 (50.0)7/26 (26.9)0.15
  • Data are shown as n (%) or median [interquartile range].

  • a One missing value.

  • b Two missing values.

  • c Eight missing values.

  • d Nine missing values.

  • e Four missing values.

  • f Five missing values.