Table 3.

Univariate and multivariable competing risk analyses for time to ESRD using death as a competing risk from 106 people with biopsy-proven diabetic glomerulosclerosis (1995–2011)

CharacteristicsUnivariate Models SHR (95% CI)P ValueGlomerular Model SHR (95% CI)P ValueFully Adjusted Model SHR (95% CI)P Value
Clinical characteristics
 Age, per 10 yr0.88 (0.72 and 1.06)0.20.71 (0.56 and 0.89)<0.010.71 (0.56 and 0.90)<0.01
 Female sex0.90 (0.54 and 1.49)0.70.77 (0.44 and 1.33)0.40.76 (0.44 and 1.33)0.3
 Black race2.18 (1.27 and 3.72)<0.011.46 (0.79 and 2.68)0.21.47 (0.79 and 2.70)0.2
 Baseline eGFR, per 10 ml/min per 1.73 m20.81 (0.69 and 0.94)0.010.72 (0.57 and 0.92)<0.010.75 (0.62 and 0.92)<0.01
 Baseline proteinuria, per 2 g/g1.05 (0.99 and 1.12)0.10.96 (0.85 and 1.08)0.50.95 (0.83 and 1.08)0.5
Glomerular characteristics
 RPS diabetic nephropathy class1.17 (0.82 and 1.66)0.4
 Mild mesangial expansion0.69 (0.53 and 0.91)0.010.61 (0.40 and 0.95)0.030.64 (0.40 and 1.00)0.05
 Mod-severe mesangial expansion1.02 (0.84 and 1.24)0.8
 Global glomerulosclerosis1.40 (1.03 and 1.90)0.030.95 (0.70 and 1.29)0.8
 Kimmelstiel–Wilson nodules1.22 (0.98 and 1.52)0.081.02 (0.78 and 1.32)0.9
 SS1.98 (1.48 and 2.65)<0.00012.17 (1.42 and 3.35)<0.0012.04 (1.36 and 3.05)<0.001
 Mesangiolysis1.13 (0.89 and 1.43)0.3
 Glomerular hyalinosis1.54 (0.93 and 2.57)0.090.73 (0.36 and 1.48)0.4
 EXHC1.88 (0.93 and 3.75)0.082.17 (1.16 and 4.05)0.022.21 (1.19 and 4.11)0.01
Interstitial characteristics
 Interstitial fibrosis2.10 (1.37 and 3.21)<0.0011.01 (0.58 and 1.77)0.9
 Interstitial Inflammation0.81 (0.37 and 1.74)0.6
Vascular characteristics
 Arteriolosclerosis1.67 (1.10 and 2.52)0.021.01 (0.64 and 1.61)>0.99
 Arteriosclerosis1.30 (0.92 and 1.83)0.1
  • The Glomerular Model=clinical covariates (regardless of P value) and glomerular variables significant to P<0.1 in univariate models. The Fully Adjusted Model=clinical covariates (regardless of P value), glomerular variables significant to P<0.1 in the Glomerular Model, and interstitial and vascular variables significant to P<0.10 in univariate models. SHR, subdistribution hazards ratio; –, not included, Mod-severe, moderate to severe.