Characteristics | Univariate Models SHR (95% CI) | P Value | Glomerular Model SHR (95% CI) | P Value | Fully Adjusted Model SHR (95% CI) | P Value |
---|---|---|---|---|---|---|

Clinical characteristics | ||||||

Age, per 10 yr | 0.88 (0.72 and 1.06) | 0.2 | 0.71 (0.56 and 0.89) | <0.01 | 0.71 (0.56 and 0.90) | <0.01 |

Female sex | 0.90 (0.54 and 1.49) | 0.7 | 0.77 (0.44 and 1.33) | 0.4 | 0.76 (0.44 and 1.33) | 0.3 |

Black race | 2.18 (1.27 and 3.72) | <0.01 | 1.46 (0.79 and 2.68) | 0.2 | 1.47 (0.79 and 2.70) | 0.2 |

Baseline eGFR, per 10 ml/min per 1.73 m^{2} | 0.81 (0.69 and 0.94) | 0.01 | 0.72 (0.57 and 0.92) | <0.01 | 0.75 (0.62 and 0.92) | <0.01 |

Baseline proteinuria, per 2 g/g | 1.05 (0.99 and 1.12) | 0.1 | 0.96 (0.85 and 1.08) | 0.5 | 0.95 (0.83 and 1.08) | 0.5 |

Glomerular characteristics | ||||||

RPS diabetic nephropathy class | 1.17 (0.82 and 1.66) | 0.4 | – | – | – | – |

Mild mesangial expansion | 0.69 (0.53 and 0.91) | 0.01 | 0.61 (0.40 and 0.95) | 0.03 | 0.64 (0.40 and 1.00) | 0.05 |

Mod-severe mesangial expansion | 1.02 (0.84 and 1.24) | 0.8 | – | – | – | – |

Global glomerulosclerosis | 1.40 (1.03 and 1.90) | 0.03 | 0.95 (0.70 and 1.29) | 0.8 | – | – |

Kimmelstiel–Wilson nodules | 1.22 (0.98 and 1.52) | 0.08 | 1.02 (0.78 and 1.32) | 0.9 | – | – |

SS | 1.98 (1.48 and 2.65) | <0.0001 | 2.17 (1.42 and 3.35) | <0.001 | 2.04 (1.36 and 3.05) | <0.001 |

Mesangiolysis | 1.13 (0.89 and 1.43) | 0.3 | – | – | – | – |

Glomerular hyalinosis | 1.54 (0.93 and 2.57) | 0.09 | 0.73 (0.36 and 1.48) | 0.4 | – | – |

EXHC | 1.88 (0.93 and 3.75) | 0.08 | 2.17 (1.16 and 4.05) | 0.02 | 2.21 (1.19 and 4.11) | 0.01 |

Interstitial characteristics | ||||||

Interstitial fibrosis | 2.10 (1.37 and 3.21) | <0.001 | – | – | 1.01 (0.58 and 1.77) | 0.9 |

Interstitial Inflammation | 0.81 (0.37 and 1.74) | 0.6 | – | – | – | – |

Vascular characteristics | ||||||

Arteriolosclerosis | 1.67 (1.10 and 2.52) | 0.02 | – | – | 1.01 (0.64 and 1.61) | >0.99 |

Arteriosclerosis | 1.30 (0.92 and 1.83) | 0.1 | – | – | – | – |

The Glomerular Model=clinical covariates (regardless of

*P*value) and glomerular variables significant to*P*<0.1 in univariate models. The Fully Adjusted Model=clinical covariates (regardless of*P*value), glomerular variables significant to*P*<0.1 in the Glomerular Model, and interstitial and vascular variables significant to*P*<0.10 in univariate models. SHR, subdistribution hazards ratio; –, not included, Mod-severe, moderate to severe.