Table 1.

Outcomes of patients by treatment group

Outcome ParameterEarly, n=112Delayed, n=119P ValueAbsolute Difference Early − Delayed [95% CI], %OR, Early Versus Delayed [95% CI]
Primary outcome
 MAKE 1 yr,a  no./no. total (%)72/111 (64.9)106/119 (89.1)<0.001−24.2 [−34.7 to −13.7]0.23 [0.11 to 0.45]
Secondary outcomes
 1-yr all-cause  mortality, no. (%)56/111 (50.2)83/119 (69.8)<0.01−19.6 [−32.0 to −7.2]0.62 [0.44 to 0.87]
 Requirement of RRT  1 yr, no./no. total (%)4/55 (7.3)4/36 (11.1)0.71−3.8 [−16.2 to 8.5]0.62 [0.15 to 2.69]
 PRD 1 yr,b  no./no. total (%)16/55 (29.1)23/36 (63.9)0.001−34.8 [−54.6 to −15.0]0.23 [0.09 to 0.57]
  • a MAKE is defined as mortality at 1 yr, RRT at 1 yr, and PRD defined as 25% decline in eGFR.

  • b PRD defined as 25% decline in eGFR.