Table 2.

First point of detection for commonly used protein markers of mature tubule segments in the human kidney

Gene SymbolGene NameStage First ObservedGudmap Ontology Number
LRP2LDL Receptor Related Protein 2Proximal segment of SSB27764
SLC3A1Solute Carrier Family 3 Member 1Proximal segment of SSB; early proximal tubule27764; 27784
SLC12A1Solute Carrier Family 12 Member 1Immature loop of Henle ascending limb35426
SLC12A3Solute Carrier Family 12 Member 3Early distal tubule (after capillary loop stage)28390
CUBNCubilinEarly proximal tubule27784
PODXLPodocalyxin LikeProximal renal vesicle; visceral epithelium of SSB31549; 27766
WT1Proximal renal vesicle; visceral epithelium of SSB; proximal segment of SSB31549; 27766; 27764
NPHS2PodocinVisceral epithelium of SSB27766
MAFBProximal renal vesicle; visceral epithelium of SSB31549; 27766
UMODUromodulinEarly distal tubule (after capillary loop stage)28390
AQP1Aquaporin 1Early proximal tubule (after capillary loop stage)27784
  • Proteins detected in figures are summarized and related to data on whether proteins are causative of human or mouse kidney disease/phenotype.