Table 2.

Postdonation outcomes between live kidney donors on the basis of APOL1 renal risk genotype

Postdonation OutcomesHigh-Risk Genotype, n=19Low-Risk Genotype, n=117P Value
Time since donation, yr11.3 [9.1–12.5]11.6 [9.1–13.6]0.75
Postdonation weight, kg89±1888±180.72
Change in weight since donation, kg+4.8±17+5.5±170.87
Systolic BP, mm Hg128±12130±190.70
Change in systolic BP since donation, mm Hg+7±12+10±190.48
Diastolic BP, mm Hg82±1083±270.81
Change in diastolic BP since donation, mm Hg+10±12+7±120.89
Hypertension, %44490.74
Treated for hypertension with medication, %75670.29
Serum creatinine, mg/dl1.71±1.21.26±0.30.003
CKD-EPI eGFR, ml/min per 1.732 m257±2067±150.02
CKD-EPI eGFR <60 ml/min per 1.732 m2, %67360.01
MDRD eGFR, ml/min per 1.732 m258±2068±140.01
MDRD eGFR <60 ml/min per 1.732 m2, %5332<0.01
ESRD, %1100.02
uACR, mg/g8.39 [2.6–23.0]4.99 [2.5–11.6]0.01
Microalbuminuria, %16100.86
  • High-risk genotype is defined as carrying two APOL1 renal risk alleles, and low-risk genotype is defined as carrying one or zero APOL1 renal risk alleles. Data are presented as mean±SD if normally distributed or median [interquartile range] in not normally distributed. To convert serum creatinine from milligrams per deciliter to micromoles per liter, multiply by 88. ESRD was defined by receipt of dialysis or kidney transplant. Microalbuminuria was defined as uACR>30 mg/g or >3 mg/mmol. MDRD, Modification of Diet in Renal Disease.