Table 1.

Calculated IC50 values for complement inhibitory capacity

Complement Assay and InhibitorIC50 Values, nMR295% Confidence Interval
AP ELISA (C5b-9)
 MFHR13.20.872.73 to 3.8
 Eculizumab17.50.8612.3 to 25
 Mini-FH12.40.838.4 to 18
 hFH1670.88126 to 222
 FHR-127480.14666 to 11,300
CP ELISA (C5b-9)
 MFHR115.90.826.4 to 40
AP ELISA (C3b deposition)
 MFHR112.40.848.3 to 18.6
 EculizumabNo activity
 Mini-FH40.40.7025 to 64
 hFH5130.82356 to 739
 FHR-1No activity