Table 1.

Biochemical and physical characteristics of mice in the four groups before and after 4 weeks of AdipoRon treatment

Characteristicsdb/m Contdb/m AdipoRondb/db Contdb/db AdipoRon16 w db/db Cont
Body weight, g36.2±1.737.2±1.853.0±7.3a51.1±4.8a49.9±3.4a
Kidney weight, g0.20±0.040.21±0.030.21±0.040.21±0.010.22±0.01
Heart weight, g0.18±0.020.18±0.020.18±0.040.17±0.020.17±0.03
FBS, mg/dl152±14138±7534±89a532±93a640±150a
HbA1c, %4.0±0.23.9±0.210.5±0.49a11.5±0.8a8.8±0.7b
HOMAIR0.06±0.010.06±0.012.37±0.02a0.21±0.01b2.11±0.11a
Total cholesterol, mmol/L2.70±0.412.65±0.513.51±0.42c3.39±0.55c3.80±0.50c
Triacylglycerols, mmol/L1.21±0.211.32±0.192.18±0.33a1.60±0.22c1.96±0.29a
Nonesterified fatty acid, mmol/L0.62±0.220.67±0.191.42±0.20c1.21±0.15c1.41±0.21c
24-h albuminuria, µg/d10.0±2.08.2±2.8223.0±51.9a100.0±18.8b163.2±30.3a
Urine volume, ml0.8±0.21.0±0.214.5±4.5a10.3±3.4a,c11.4±4.3a,c
Serum Cr, µmol/L17.1±3.117.3±1.719.3±3.717.5±3.918.3±3.1
Ccr, ml/min0.36±0.110.32±0.231.13±0.34a0.74±0.25c1.15±0.33a
Mean systolic BP, mm Hg101±7102±5106±7103±4105±4
Serum adiponectin, μg/ml10.6±1.210.8±1.44.6±0.5a4.7±0.9a4.5±0.7a
  • Data are mean±SD. Cont, control; FBS, fasting blood sugar; HbA1c, Hemoglobin A1c; HOMAIR, homeostatic model assessment of insulin resistance; Cr, Creatinine; Ccr, creatinine clearance.

  • a P<0.001 compared with other groups.

  • b P<0.01 compared with other groups.

  • c P<0.05 compared with other groups.