Table 1.

Clinical characteristics and biopsy findings of living kidney donors and patients who underwent a tumor nephrectomy

CharacteristicKidney Donors (n=2453)Patients with Renal Tumor (n=780)P Value
Demographic
 Age, yr43.7 (11.8)63.6 (12.2)<0.001
  ≤602229 (90.9%)306 (39.2%)
  61–75221 (9.0%)344 (44.1%)
  >753 (0.1%)130 (16.7%)
 Men, %1019 (41.5%)499 (64.0%)<0.001
 Height, cm170.7 (9.5)172.4 (9.9)<0.001
Risk factors
 Diabetes mellitus, %0 (0%)117 (15.0%)<0.001
 Hypertension, %238 (9.7%)505 (64.7%)<0.001
 Known family history of ESRD, %1259 (51.3%)0 (0.0%)<0.001
 Body mass index, kg/m227.5 (4.8)30.0 (6.5)<0.001
Kidney function
 eGFR, ml/min per 1.73 m292.4 (16.2)70.9 (19.8)<0.001
  <60 ml/min per 1.73 m224 (1.0%)211 (27.1%)<0.001
 24-h urine protein, mga46.3 (35.8)584 (2157)<0.001
  >500 mg0 (0.0%)103 (18.9%)<0.001
Biopsy measures
 Biopsy area, mm26.7 (2.9)28.9 (0.4)<0.001
 NSG tuft volume, mm30.0026 (0.0010)0.0029 (0.0012)<0.001
 Number of NSG on biopsy17.8 (9.9)75.8 (23.5)<0.001
 GSG volume, mm3b0.0008 (0.0003)0.0011 (0.0005)<0.001
 Number of GSG on biopsy0.6 (1.0)8.9 (15.3)<0.001
 Ischemic-appearing NSG, %<0.001
  0–52323 (94.7%)642 (82.3%)
  6–1088 (3.6%)89 (11.4%)
  >1042 (1.7%)49 (6.3%)
 GSG of all glomeruli, %<0.001
  0–102184 (89.0%)515 (66.0%)
  11–25230 (9.4%)199 (25.5%)
  >2539 (1.6%)66 (8.5%)
 Interstitial fibrosis, %<0.001
  0–102436 (99.3%)717 (91.9%)
  11–2517 (0.7%)22 (2.8%)
  >250 (0%)41 (5.3%)
 Luminal stenosis, %c<0.001
  ≤501709 (78.3%)241 (30.9%)
  >50473 (21.7%)539 (69.1%)
  • Data are presented as mean (SD) or n %.

  • a n=2003 for donors, n=545 for patients with renal tumor.

  • b Analysis was limited to 268 donors and 632 patients with renal tumor with two or more GSG profiles, although means were the same for the 763 donors and 709 patients with renal tumor with one or more GSG profile.

  • c n=2182 donors (89%) and all patients with renal tumor had an artery present on the biopsy specimen.