Table 1.

Characteristics at baseline (intention-to-treat population)

CharacteristicEverolimus (n=1022)MPA (n=1015)
Mean age (SD), yr49.3 (14.1)49.3 (14.5)
Male, n (%)710 (69.5)707 (69.7)
Race, n (%)
 White743 (72.7)735 (72.4)
 Asian136 (13.3)157 (15.5)
 Black43 (4.2)35 (3.4)
 Other100 (9.8)88 (8.7)
Mean BMI (SD), kg/m225.6 (4.2)25.6 (4.3)a
ESRD leading to transplant, n (%)
 Glomerular disease157 (15.4)176 (17.3)
 Polycystic disease147 (14.4)149 (14.7)
 Diabetes mellitus128 (12.5)131 (12.9)
 Hypertension/nephrosclerosis124 (12.1)125 (12.3)
 IgA nephropathy88 (8.6)103 (10.1)
 Other377 (36.9)331 (32.6)
 Missing1 (0.1)0 (0.0)
Diabetes at baseline, n (%)279 (27.3)269 (26.5)
Hemodialysis, n (%)674 (65.9)679 (66.9)
Mean PRA (SD) (most recent evaluation)2.7 (10.7)2.7 (9.5)
HLA mismatching, n (%)
 Loci A
  0178 (17.4)172 (16.9)
  1550 (53.8)545 (53.7)
  2286 (28.0)295 (29.1)
  Missing8 (0.8)3 (0.3)
 Loci B
  0114 (11.2)124 (12.2)
  1518 (50.7)494 (48.7)
  2382 (37.4)394 (38.8)
  Missing8 (0.8)3 (0.3)
 Loci DR
  0240 (23.5)193 (19.0)
  1495 (48.4)557 (54.9)
  2279 (27.3)262 (25.8)
  Missing8 (0.8)3 (0.3)
Mean cold ischemia time (SD), h8.4 (7.8)8.4 (7.8)
Delayed graft function, n (%)79 (7.7)72 (7.1)
Induction, n (%)
 Basiliximab849 (83.1)843 (83.1)
 rATG171 (16.7)171 (16.8)
 Missing2 (0.2)1 (0.1)
Donor
 Mean age (SD), yr48.4 (15.18)48.2 (15.48)
 Male, n (%)493 (48.2)508 (50.0)
 Race, n (%)
  White620 (60.7)599 (59.0)
  Asian120 (11.7)134 (13.2)
  Other282 (27.6)279 (27.5)
Donor category, n (%)
 Living related302 (29.5)315 (31.0)
 Living unrelated209 (20.5)192 (18.9)
 Deceased heart-beating506 (49.5)505 (49.8)
 Deceased non-heart-beating5 (0.5)3 (0.3)
Donor criteria, n (%)a
 Standard criteria deceased donor354 (70.0)345 (68.3)
 Expanded criteria deceased donor152 (30.0)160 (31.7)
CMV serology, n/N (%)
 D+/R−153 of 978 (15.6)139 of 976 (14.2)
 D+/R+514 of 978 (52.6)522 of 976 (53.5)
 D−/R+141 of 978 (14.4)147 of 976 (15.1)
 D−/R−170 of 978 (17.4)168 of 976 (17.2)
  • BMI, body mass index; IgA, immunoglobulin A; PRA, panel reactive antibodies; HLA, human leukocyte antigen; D, donor; R, recipient.

  • a Denominator is the number of deceased heart-beating donors.