Table 1.

Replication and combined analysis of SNPs in HLA-DR/DQ region

CHRSNPA1/A2Genetic ModelDiscovery GWAS (224 Patients versus 412 Controls)Replication (216 Patients versus 719 Controls)Combined Analysis
(440 Patients versus 1131 Controls)
PatientsControlsP-FisherOR (95% CI)PatientsControlsP-FisherOR (95% CI)PatientsControlsP-FisherOR (95% CI)
6rs4642516G/TAllelic0.11a0.26b1.06E−100.36 (0.26 to 0.50)0.10a0.28b4.51E−150.30 (0.22 to 0.42)0.11a0.27b7.84E−230.33 (0.26 to 0.41)
Dominant47 of 177194 of 2185.29E−110.30 (0.21 to 0.43)43 of 173336 of 3813.43E−130.28 (0.20 to 0.41)90 of 350530 of 5994.87E−230.29 (0.22 to 0.38)
6rs3134996A/TAllelic0.09a0.23b4.85E−110.32 (0.22 to 0.46)0.12a0.32b1.26E−150.30 (0.22 to 0.41)0.10a0.28b1.72E−250.29 (0.23 to 0.37)
Dominant37 of 187168 of 2441.86E−100.29 (0.19 to 0.43)34 of 163265 of 3636.24E−110.29 (0.19 to 0.43)71 of 350433 of 6079.57E−210.28 (0.21 to 0.38)
  • CHR, chromosome; A1, minor allele (test allele); A2, major allele (reference allele); P-Fisher, P value calculated using Fisher’s exact test.

  • a MAF in patients.

  • b MAF in controls.