Table 3.

Validation, replication and combined analyses of the significant HLA-DRB1/-DQB1 alleles and HLA-DRB1-DQB1 haplotypes

HLA Alleles/HaplotypesaValidationReplicationCombined Analysis
Patients (2n=448)
No. (%)Controls (2n=818)
No. (%)Chi-Squared TestPatients (2n=426)
No. (%)Controls (2n=1420)
No. (%)Chi-Squared TestPatients (2n=874)
No. (%)Controls (2n=2238)
No. (%)Chi-Squared Test
OR (95% CI)PcbOR (95% CI)PcbOR (95% CI)Pcb
DRB1*08:0246 (10.3)32 (3.9)2.81 (1.76 to 4.48)1.24E−0444 (10.3)62 (4.4)2.52 (1.69 to 3.77)6.64E−0590 (10.3)94 (4.2)2.62 (1.94 to 3.54)1.82E−09
DRB1*13:025 (1.1)55 (6.7)0.16 (0.06 to 0.39)1.28E−047 (1.6)125 (8.8)0.17 (0.08 to 0.37)9.32E−0612 (1.4)180 (8.0)0.16 (0.09 to 0.29)7.31E−11
DQB1*03:0280 (17.9)77 (9.4)2.09 (1.49 to 2.93)1.44E−0448 (11.3)136 (9.6)1.20 (0.85 to 1.70)NS128 (14.6)213 (9.5)1.63 (1.29 to 2.06)4.25E−04
DQB1*06:0215 (3.4)65 (8.0)0.40 (0.23 to 0.71)1.43E−0214 (3.3)108 (7.6)0.41 (0.23 to 0.73)1.81E−0229 (3.3)173 (7.7)0.41 (0.27 to 0.61)7.84E−05
DQB1*06:042 (0.5)53 (6.5)0.06 (0.02 to 0.27)5.26E−065 (1.2)117 (8.2)0.13 (0.05 to 0.33)2.89E−077 (0.8)170 (7.6)0.10 (0.05 to 0.21)2.09E−12
DRB1*08:02-DQB1*03:0236 (8.0)17 (2.1)4.12 (2.28 to 7.42)8.76E−0628 (6.6)31 (2.2)3.15 (1.87 to 5.32)1.25E−0464 (7.3)48 (2.1)3.60 (2.46 to 5.29)7.01E−11
DRBQ*13:02-DQB1*06:042 (0.5)53 (6.5)0.06 (0.02 to 0.27)1.00E−055 (1.2)117 (8.2)0.13 (0.05 to 0.33)5.25E−067 (0.8)170 (7.6)0.10 (0.05 to 0.21)4.18E−12
DRB1*15:01-DQB1*06:0215 (3.4)65 (8.0)0.40 (0.23 to 0.71)2.74E−0214 (3.3)107 (7.5)0.42 (0.24 to 0.74)3.77E−0229 (3.3)172 (7.7)0.41 (0.28 to 0.62)1.85E−04
  • 2n, counts of HLA alleles/haplotypes; NS, Pc≥0.05.

  • a Alleles/haplotypes, significant HLA-DRB1/-DQB1 alleles and HLA-DRB1-DQB1 haplotypes identified in the discovery stage using HLA-imputation data.

  • b Pc, P values for haplotype frequency comparisons between patients and controls using the Pearson’s chi-squared test or Fisher’s exact test and then corrected for multiplicity of testing on the basis of the number of comparisons.