Table 2.

Adjusted mortality HRs (95% CIs) for patients who initiated dialysis compared with patients who received medical management, stratified by time-varying age and eGFR

Time-Varying eGFR, ml/min per 1.73 m2Time-Varying Age
<6565–7475–84>85
<60.28 (0.16 to 0.45)0.37 (0.22 to 0.62)0.34 (0.20 to 0.57)0.36 (0.21 to 0.63)
6 to <90.41 (0.32 to 0.52)0.87 (0.64 to 1.18)0.37 (0.30 to 0.45)0.39 (0.30 to 0.50)
9 to <120.83 (0.67 to 1.02)0.86 (0.68 to 1.09)0.74 (0.63 to 0.88)0.61 (0.49 to 0.75)
12 to <150.88 (0.70 to 1.11)1.49 (1.18 to 1.87)1.20 (1.05 to 1.37)1.08 (0.86 to 1.36)
15–291.50 (1.32 to 1.71)1.76 (1.55 to 1.99)1.78 (1.63 to 1.95)2.04 (1.74 to 2.40)
>293.70 (2.99 to 4.58)3.76 (2.87 to 4.92)3.16 (2.59 to 3.87)3.37 (2.40 to 4.73)
  • Model includes main effects for age, eGFR, dialysis, and interactions between age×eGFR, age×dialysis, and eGFR×dialysis, in addition to index eGFR, eGFR slope, sex, race, marital status, ZIP code median income, distance to VA facility, VA facility complexity, VA copayment, residence, chronic conditions (diabetes, ischemic heart disease, heart failure, peripheral arterial disease, cerebrovascular disease, paralysis, chronic pulmonary disease, chronic liver disease, connective tissue disease, peptic ulcer disease, malignancy, metastatic solid tumor, AIDS, dementia, and depression), cumulative hospital and nursing facility days, calendar year, and correlation of patients within facilities.