Table 2.

Association of time-updated incident AF with risk of subsequent cardiovascular events and death in adults with CKD

Cardiovascular EventsNumber of EventsUnadjustedModel 1Model 2
HR (95% CI)HR (95% CI)HR (95% CI)
HF
 No incident AF344RefRefRef
 Incident AF665.99 (4.55–7.89)6.06 (4.59–8.01)5.17 (3.89–6.87)
Acute MI
 No incident AF198RefRefRef
 Incident AF364.81 (3.33–6.95)4.28 (2.95–6.22)3.64 (2.50–5.31)
Stroke
 No incident AF106RefRefRef
 Incident AF153.47 (1.98–6.09)3.14 (1.78–5.54)2.66 (1.50–4.74)
Death
 No incident AF461RefRefRef
 Incident AF1114.50 (3.64–5.57)4.14 (3.33–5.15)3.30 (2.65–4.12)
Composite outcome of HF, acute MI, stroke, and death
 No incident AF827RefRefRef
 Incident AF1124.38 (3.57–5.36)4.20 (3.42–5.15)3.68 (2.99–4.53)
  • Model 1: adjusted for age, sex, race/ethnicity, clinical site. Model 2: adjusted for model 1 plus diabetes, hypertension, any history of CVD, tobacco use, systolic BP, BMI, eGFR, proteinuria, BMI, LDL cholesterol, HDL cholesterol, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use, β-blocker use, and diuretic use. Ref, reference value.