Table 2.

Biochemical parameters

ParameterControl BaselineControl 12 moChanges,a Absolute/%Zoledronate BaselineZoledronate 12 moChanges,a Absolute/%P Value TransplantP Value Zoledronate versus ControlP Value Interaction
Calcium, mg/dl8.3±0.79.6±0.51.3/15.78.5±0.59.5±0.61.0/11.8<0.0010.640.43
Phosphorus, mg/dl6.7±1.33.2±0.8−3.5/−52.27.9±2.03.2±0.8−3.8/−48.1<0.0010.060.07
AP, UI/L125±57114±57−11/−8.8114±8570.6±21.6−43.4/−380.040.100.19
PTH, pg/ml527±431110±160−417/−79.1437±32491±62−346/−79.2<0.0010.460.58
25OH vit.D, ng/ml28.5±7.630.2±14.41.7/6.023.9±20.528.4±8.04.5/18.80.180.330.54
Sclerostin, ng/ml1.05±0.620.52±0.16−0.53/−501.47±1.00.55±0.14−0.92/−62.6<0.0010.160.17
BAP, UI/L100±6245.3±28.7−54.7/−54.792±7422.4±6.8−69.6/−75.6<0.0010.230.54
TRAP5b, UI/L10.2±4.44.9±2.6−5.3/−51.99.6±4.52.3±1.4−7.3/−76<0.0010.070.20
  • Variables are presented as mean ± SD. P values are derived from a linear mixed model. AP, alkaline phosphatase; 25OH vit.D, 25 (OH) vitamin D; BAP, bone-specific alkaline phosphatase; TRAP5b, tartrate-resistant acid phosphatase.

  • a Changes according to groups.