Table 1.

Mouse models with an IgA nephropathy–like disease manifestation

ModelGlomerular IgA Deposits (Species)Total IgA Levels in BloodGFRProteinuriaHematuriaGlomerular Pathology
Present study1
 AID wild-type mice++ (Human)↑ about fivefoldNormalNoneNoneMild mesangial expansion and C3 deposition
 AID-deficient mice+++ (Human)↑ about 50-foldReducedNoneNoneMesangial expansion and C3 deposition
Mice expressing human IgA1 and CD89+++ (Human)↑ >100-foldMildly reduced+++Mesangial expansion and C3 deposition
High-IgA mice+++ (Mouse)↑ up to fourfoldReduced+NoneMesangial expansion and C3 deposition
β-1,4-galactosyl-transferase–deficient mice++ (Mouse)↑ up to tenfoldNo data+++Mesangial expansion and C3 deposition
CD37-deficient mice+++ (Mouse)↑ up to 15-foldNormalNoneNoneMesangial expansion and hypercellularity; no data on C3
BAFF transgenic mice+++ (Mouse)↑ up to 50-foldESRD at 17 mo+++++Mesangial matrix expansion; no data on C3; little C4
Uteroglobin-deficient mice+++ (Mouse)No dataNo dataNo data+++Mesangial matrix expansion and C3 deposition
LIGHT transgenic mice+++ (Mouse)↑ 30- to 40-foldNo data+++Mesangial matrix expansion and C3 deposition
MBP20 peptide fusion protein+++ (Mouse)No dataNo data(+)++Mesangial matrix expansion and proliferation and C3 deposition
Monoclonal IgA from Peyer patch hybridomas of vomitoxin-exposed mice++ (Mouse)↑ two- to four-foldNo dataNo data+Normal mesangium, C3 deposition
  • AID, activation-induced cytidine deaminase. Modified from ref. 9, with permission.