Table 1.

Classic cell type selective markers

Cell TypeaGold Standard Marker(s)
PodocyteNphs1 (nephrin), Nphs2 (podocin)
Proximal S1 cellSlc5a2 (SGLT2)
Proximal S2 cellSlc22a6 (OAT1)
Proximal S3 cellAgt (angiotensinogen)
All proximal tubuleSlc34a1 (Na-Pi2), Lrp2 (megalin)
DTL type 1 cellSlc14a2 (UT-A2)
DTL type 2 cellSlc14a2 (UT-A2)
DTL type 3 cellSlc14a2 (UT-A2)
Ascending thin limb cellClcnka (chloride channel Ka)
MTAL limb cellSlc12a1 (NKCC2), Umod (Tamm–Horsfall protein)
CTAL cellSlc12a1, Umod
Macula densa cellSlc12a1, Oxtr (oxytocin receptor), Nos1 (nitric oxide synthase 1)
Distal convoluted tubule cellSlc12a3 (NCC)
CNT cellAqp2 (aquaporin-2), Scnn1g (γ-ENaC), Calb1 (calbindin)
PC (CCD)Aqp2, Scnn1g
PC (OMCD)Aqp2, Scnn1g
Type A ICSlc4a1 (anion exchanger 1)
Type B ICSlc26a4 (pendrin)
IMCD cellAqp2, Slc14a2 (UT-A1)
  • a Cell type markers identified in the pregenomic era.