Table 3.

Clinical characteristics and biologic data after exclusion of Het carriers with HTN or diabetes history and patients with GS treated with potassium-sparing diuretics

CharacteristicHS (n=82)Het (n=74)GS (n=79)ANOVA P Value
Plasma
 Creatinine, µmol/L66 [59; 76]a65 [58; 72]59 [50; 72]0.01
 eGFR, ml/min per 1.73 m292 [81; 110]103 [89; 114]99 [86; 110]0.1
 Sodium, mmol/L140 [139; 141]a140 [139; 142]a139 [138; 141]0.01
 Potassium, mmol/L4.0 [3.8; 4.2]b3.9 [3.7; 4.1]b2.8 [2.5; 3.1]<0.001
 CO2t, mmol/L27 [26; 28]b27 [26; 29]b30 [28; 32]<0.001
 Calcium, mmol/L2.24 [2.18; 2.29]b2.26 [2.21; 2.34]b,c2.34 [2.26; 2.39]<0.001
 Magnesium, mmol/L0.80 [0.75; 0.83]b0.80 [0.78; 0.84]b0.59 [0.51; 0.67]<0.001
 PTH 7–84, pg/ml44 [34; 55]b39 [31; 46]b31 [24; 39]<0.001
 PRC, mUI/L15 [9; 21]b16 [11; 23]b109 [53; 154]<0.001
 PAC, pmol/L178 [136; 235]b213 [154; 305]b311 [241; 525]<0.001
Urinary excretion
 Output, L/24 h1.6 [1.1; 1.9]a1.4 [1.0; 2.1]a1.7 [1.4; 2.3]a0.02
 Creatinine, mmol/24 h11.9 [9.0; 15.0]a11.2 [8.8; 14.2]11.8 [9.9; 15.3]0.46
 Sodium, mmol/24 h147 [99; 172]b133 [93; 189]c183 [105; 246]<0.001
 Potassium, mmol/24 h59 [44; 75]b58 [47; 79]b108 [92; 154]<0.001
 Calcium, mmol/24 h3.8 [2.6; 5.6]b3.5 [2.2; 5.2]b1.1 [0.7; 2.0]<0.001
 Calcium-to-creatinine ratio, mM/mM0.32 [0.23; 0.52]b0.32 [0.19; 0.47]b0.09 [0.05; 0.18]<0.001
 Magnesium, mmol/24 h3.4 [2.5; 4.2]b3.3 [2.7; 4.3]b4.4 [3.6; 6.1]<0.001
 Aldosterone, nmol/24 h56 [33; 87]b67 [48; 95 ]95 [72; 172]<0.001
  • eGFR calculated with cystatin C-based CKD Epidemiology Collaboration. Data are presented as medians [IQR]. Difference between groups was evaluated first with ANOVA. If significant, Dunn test was performed to compare HS versus GS and Het versus GS (a,b) and Tukey test was performed to compare HS and Het (c). CO2t, Total CO2; PRC, plasma renin concentration; PAC, plasma aldosterone concentration.

  • a P<0.05.

  • b P<0.001.

  • c P<0.05.