Table 2.

Mediation analysis of the effect of the SBP intervention on the CVD composite and all-cause mortality

Type of EffectCVD CompositeAll-Cause Mortality
Risk Ratio95% CIRisk Ratio95% CI
Indirect effect0.990.95 to 1.031.000.95 to 1.06
Direct effect0.680.57 to 0.790.810.64 to 1.01
Total effect0.670.56 to 0.780.810.65 to 1.00
  • The hazard ratio for the total effects of the SBP intervention on the CVD composite and all-cause mortality can be represented approximately as the product of the corresponding hazard ratios for the indirect and direct effects. Thus, for the CVD composite, 0.67=0.99×0.68. For all cause-mortality, 0.81=1.00×0.81. Model adjusted for baseline age, sex, race, SBP, diastolic BP, CVD, smoking, eGFR, urine albumin-to-creatinine ratio, and Framingham 10-year CVD risk score.