Table 4.

Donor baseline CT and biopsy predictors of death-censored graft failure among donors who had arteriolar hyalinosis assessed on biopsy (n=1585)

Structural FeatureaUnadjustedAdjusted for Donors CovariatesbAdjusted for Recipients CovariatescAdjusted for Both Donors and Recipients Covariatesb,c
HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)
% Globally sclerotic glomeruli1.02 (0.89 to 1.16)0.99 (0.86 to 1.15)1.07 (0.94 to 1.23)1.00 (0.87 to 1.16)
Glomerulosclerosis above age thresholdd0.69 (0.35 to 1.35)0.69 (0.36 to 1.35)0.82 (0.42 to 1.61)0.80 (0.41 to 1.56)
%IF/TA
 0%ReferenceReferenceReferenceReference
 >0% to ≤5%1.12 (0.81 to 1.55)1.09 (0.78 to 1.53)1.22 (0.87 to 1.70)1.13 (0.80 to 1.58)
 >5%2.43 (1.38 to 4.29)2.33 (1.28 to 4.25)2.27 (1.27 to 4.04)1.79 (0.97 to 3.28)
IF/TA foci/mm21.05 (0.91 to 1.20)1.03 (0.89 to 1.19)1.07 (0.93 to 1.22)1.01 (0.87 to 1.16)
% Artery luminal stenosis1.03 (0.92 to 1.17)1.01 (0.89 to 1.15)1.08 (0.96 to 1.23)1.03 (0.90 to 1.17)
Nonsclerotic glomeruli volume1.09 (0.96 to 1.23)1.09 (0.97 to 1.23)1.12 (0.99 to 1.26)1.13 (1.00 to 1.28)
Tubular cross-sectional area1.17 (1.04 to 1.31)1.17 (1.04 to 1.31)1.16 (1.03 to 1.31)1.16 (1.03 to 1.31)
Cortical volume per glomerulus1.03 (0.92 to 1.16)1.03 (0.91 to 1.16)1.07 (0.95 to 1.21)1.06 (0.94 to 1.20)
Cortex volume0.99 (0.87 to 1.14)1.01 (0.88 to 1.15)0.98 (0.86 to 1.12)1.02 (0.89 to 1.17)
Medulla volume0.90 (0.79 to 1.03)0.89 (0.78 to 1.02)0.86 (0.75 to 0.99)0.84 (0.73 to 0.96)
Kidney surface roughness0.99 (0.87 to 1.14)0.98 (0.86 to 1.13)1.01 (0.88 to 1.16)0.98 (0.86 to 1.13)
Any kidney cyst0.82 (0.49 to 1.39)0.78 (0.46 to 1.33)0.90 (0.53 to 1.52)0.77 (0.45 to 1.31)
Nephron number0.94 (0.80 to 1.10)0.96 (0.81 to 1.12)0.90 (0.77 to 1.05)0.94 (0.80 to 1.10)
Single-nephron GFR1.02 (0.90 to 1.15)1.02 (0.90 to 1.15)1.04 (0.92 to 1.18)1.04 (0.92 to 1.18)
Any arteriolar hyalinosis1.63 (1.16 to 2.31)1.59 (1.12 to 2.26)1.71 (1.19 to 2.46)1.62 (1.12 to 2.34)
  • a All HR for continuous measures are per SD.

  • b Donor age and black race.

  • c Recipient age, black race, diabetes, cause of CKD, any HLA mismatch, HLA donor-recipient mismatch, previous kidney transplant, pretransplant dialysis, and delayed graft function.

  • d Number of globally sclerotic glomeruli on biopsy exceeds 95th percentile expected for donor age and number of glomeruli.30