Table 4.

Sensitivity, specificity, PPVs, NPVs, and overall agreement for measured PCR category, and ACR category imputed from PCR using model C4, at KDIGO category thresholds (reference standard: KDIGO category of measured ACR)

KDIGO Category ThresholdComparison with Category of Measured ACRSensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)% Overall Agreement (95% CI)ROC C-Statistic (95% CI)
A1/A2KDIGO category of measured PCR79.1 (78.5 to 79.7)93.3 (93.1 to 93.6)88.0 (87.4 to 88.4)87.9 (87.5 to 88.3)87.9 (87.6 to 88.2)0.86 (0.86 to 0.87)
ACR category imputed from PCR using model with cubic spline and all covariates (C4)83.2 (82.6 to 83.7)92.3 (92.0 to 92.6)86.9 (86.4 to 87.4)89.9 (89.6 to 90.3)88.8 (88.5 to 89.1)0.95 (0.95 to 0.96)
A2/A3KDIGO category of measured PCR94.7 (94.1 to 95.2)98.0 (97.9 to 98.2)89.0 (88.3 to 89.7)99.1 (99.0 to 99.2)97.6 (97.4 to 97.7)0.96 (0.96 to 0.97)
ACR category imputed from model with cubic spline and all covariates (C4)95.4 (94.8 to 95.8)98.2 (98.0 to 98.3)89.7 (89.0 to 90.4)99.2 (99.1 to 99.3)97.8 (97.6 to 97.9)>0.99 (>0.99 to >0.99)
  • Values except ROC statistic are reported in percent. A1/A2 threshold: ACR=30 mg/g, PCR=150 mg/g. A2/A3 threshold: ACR=300 mg/g, PCR=500 mg/g. Positive cases are above the threshold. ROC, receiver operator characteristic.