Detailed description of treatment of individual cases and their outcomes at last follow-up
Case | Admission Immunosuppression | Immunosuppression Change | Anti–COVID-19 Therapy | Mechanical Ventilation Required | AKI | AKI Outcome | RRT Required | Symptoms to Intubation | Hospitalization Outcome |
---|---|---|---|---|---|---|---|---|---|
1 | Belatacept, MPA, prednisone | Held MPA, postponed belatacept | Hydroxychloroquine, azithromycin | Yes | Resolved | Deceased | |||
2 | Tacrolimus, MMF, prednisone | Held MPA | Hydroxychloroquine, azithromycin | Discharged home | |||||
3 | Tacrolimus, azathioprine, prednisone, adalimumab | Held azathioprine | Hydroxychloroquine, azithromycin | Yes | Ongoing | Discharged home | |||
4 | Tacrolimus, MMF, prednisone | Held MPA | Hydroxychloroquine, azithromycin | Yes | Resolving | Discharged home | |||
5 | Tacrolimus, MMF, prednisone | Held MMF | Hydroxychloroquine | Discharged home | |||||
6 | Tacrolimus, MMF | No change | Discharged home | ||||||
7 | Belatacept, tacrolimus, MMF, prednisone | Held MMF | Hydroxychloroquine | Discharged home | |||||
8 | Tacrolimus, MPA | Held all immunosuppression | Hydroxychloroquine, azithromycin | Discharged home | |||||
9 | Tacrolimus, MMF, prednisone | Held MMF | Hydroxychloroquine | Yes | 6 | Remains intubated (day 8 of mechanical ventilation) | |||
10 | Tacrolimus, leflunomide | Held leflunomide | Hydroxychloroquine | Discharged home | |||||
11 | Tacrolimus, MMF | Held tacrolimus and MMF, started prednisone | Yes | Yes | Ongoing | yes | 5 | Remains intubated (day 6 of mechanical ventilation) | |
12 | Tacrolimus, prednisone | Decrease prednisone and tacrolimus | Hydroxychloroquine, azithromycin, tocilizumab | Yes | yes | 5 | Extubated on day 5 | ||
13 | Tacrolimus, MMF, prednisone | Held MMF | Hydroxychloroquine, azithromycin | Yes | Yes | Resolving | 7 | Deceased | |
14 | Tacrolimus, MMF | Held MMF | Hydroxychloroquine, azithromycin | Remains hospitalized | |||||
15 | Tacrolimus, MMF, prednisone | Held MMF | Hydroxychloroquine, azithromycin | Yes | Ongoing | Remains hospitalized |
Patients 2 and 6 were admitted to other hospitals, as a result, admission lab data are not available. The remaining empty cells in the table are missing information. COVID-19, coronavirus disease 2019; MPA, mycophenolic acid; MMF, mycophenolate mofetil.