Pathologic findings in patients with COVID-19 who underwent kidney biopsy
| Pt | Diagnosis | Light Microscopy | Electron Microscopy | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Diagnosis | Other Findings | No. Glom | No. GS | No. Collapse | No. Noncollapsed FSGS | Hypercellularity | Microcysts | II | IFTA | VS | FPE | TRI | Viral Particles | |
| 1 | Collapsing FSGS | ATI | 20 | 0 | 14 | 0 | N | Y | Focal | Mild | Mild | NAa | NAa | N |
| 2 | Collapsing FSGS | ATI | 8 | 3 | 2 | 0 | N | Y | Focal | Moderate | Moderate to severe | 100 | Y | N |
| 3 | Collapsing FSGS | ATI | 18 | 4 | 4 | 1 | N | Y | None | Moderate | Moderate | 30 | N | N |
| 4 | Collapsing FSGS | ATI | 10 | 1 | 5 | 0 | N | N | Focal | Severe | Mild | NA | NA | NA |
| 5 | Collapsing FSGS | ATI | 11 | 3 | 7 | 0 | N | Y | Focal | Severe | Moderate to severe | 90 | N | N |
| 6 | MCD | ATI | 17 | 0 | 0 | 0 | N | Y | None | None | None | 100 | Y | N |
| 7 | ATI | 15 | 0 | 0 | 0 | N | N | Focal | None | Mild | 15 | Y | N | |
| 8 | ATI | Pigment casts | 22 | 0 | 0 | 0 | N | N | None | None | Mild | 10 | Y | N |
| 9 | ATI | 2 | 1 | 0 | 0 | N | N | None | Mild | Moderate | NAa | NAa | N | |
| 10 | ATI | 8 | 0 | 0 | 0 | N | N | None | None | Moderate | 5 | N | N | |
| 11 | MGN | PLA2R stain positiveb | 15 | 3 | 0 | 4 | N | N | Focal | Mild | Mild to moderate | 100 | N | N |
| 12 | MGN | PLA2R stain negativeb | 3 | 2 | 0 | 0 | N | Y | Focal | Moderate | Moderate to severe | 30 | Y | N |
| 13 | LN class 4+5 | 35 | 9 | 0 | 0 | Mes, Endo, Crescents | N | Diffuse | Mild | Mild | 90 | Y | N | |
| 14 | Anti-GBM GN | ATI, RBC casts | 32 | 1 | 0 | 0 | Crescents | Y | Diffuse | Mild | Moderate | NAa | NAa | N |
| 15 | TCMR grade 2A | 11 | 1 | 0 | 0 | N | N | Focal | None | Mild | NA | NA | NA | |
| 16 | Infarctionc | NA | NA | NA | NA | NA | N | Focal | Severe | NA | NA | NA | NA | |
| 17 | ATI | 20 | 1 | 0 | 0 | N | N | None | None | Mild | NA | NA | NA | |
Pt, patient; glom, No., number; glomerulus or glomeruli; GS, global sclerosis; II, interstitial inflammation; IFTA, tubular atrophy and interstitial fibrosis; VS, vascular sclerosis; FPE, foot process effacement (percentage); N, no; Y, yes; NA, not available; MCD, minimal change disease; LN, lupus nephritis; Mes, mesangial hypercellularity; Endo, endocapillary hypercellularity; RBC, red blood cell; TCMR, T cell–mediated rejection.
↵a All glomeruli were involved by crescents in the patient with anti-GBM GN, and no glomeruli were available for ultrastructural examination in two patients with native kidney biopsies.
↵b Performed by tissue staining.
↵c Nephrectomy specimen.