Table 2.

Comparison of histologic features between phenotypes

ParameterNo ABMRh (n=168)ABMRh (n=56)P ValueHLA-DSA Negative ABMRh (n=26)HLA-DSA Positive ABMRh (n=30)P Value
g, mean (±SD)0.05 (±0.22)1.95 (±0.94)<0.001a2.19 (±0.80)1.73 (±1.01)0.09
g≥1, n (%)9/168 (5.4)53/56 (94.6)<0.001a26/26 (100.0)27/30 (90.0)0.24
ptc, mean (±SD)0.09 (±0.43)1.07 (±0.89)<0.001a1.12 (±0.82)1.03 (±0.96)0.66
ptc≥1, n (%)9/168 (5.4)39/56 (69.6)<0.001a20/26 (76.9)19/30 (63.3)0.27
MVI score, mean (±SD)0.14 (±0.47)3.01 (±1.30)<0.001a3.31 (±1.09)2.77 (±1.43)0.13
MVI ≥2, n (%)4/168 (2.4)49/56 (87.5)<0.001a25/26 (96.2)24/30 (80.0)0.11
C4d, mean (±SD)0.12 (±0.55)0.84 (±1.16)<0.001a0.46 (±0.81)1.17 (±1.32)0.04a
C4d≥1, n (%)9/168 (5.4)24/56 (42.9)<0.001a8/26 (30.8)16/30 (53.3)0.09
v, mean (±SD)0.04 (±0.22)0.38 (±0.65)<0.001a0.42 (±0.58)0.33 (±0.71)0.29
v≥1, n (%)5/168 (3.0)17/56 (30.4)<0.001a10/26 (38.5)7/30 (23.3)0.22
cg, mean (±SD)0.07 (±0.41)0.40 (±0.81)<0.001a0.35 (±0.63)0.45 (±0.95)0.94
cg≥1, n (%)7/168 (4.2)14/56 (25.0)<0.001a7/26 (26.9)7/30 (23.3)0.77
i, mean (±SD)0.24 (±0.65)0.63 (±1.05)0.006a0.77 (±1.21)0.50 (±0.90)0.42
i≥1, n (%)25/168 (14.9)17/56 (30.4)0.01a9/26 (34.6)8/30 (26.7)0.52
t, mean (±SD)0.44 (±0.76)0.70 (±0.76)0.004a0.69 (±0.88)0.70 (±0.65)0.65
t≥1, n (%)52/168 (31.0)30/56 (53.6)0.003a12/26 (46.2)18/30 (60.0)0.30
ti, mean (±SD)0.38 (±0.79)0.57 (±0.87)0.04a0.46 (±0.86)0.67 (±0.88)0.30
ti≥1, n (%)38/168 (22.6)21/56 (37.5)0.03a8/26 (30.8)13/30 (43.3)0.33
ci, mean (±SD)0.94 (±1.10)0.68 (±0.79)0.300.54 (±0.71)0.80 (±0.85)0.25
ci≥1, n (%)87/168 (51.8)24/56 (42.8)0.5811/26 (42.3)17/30 (56.7)0.28
ct, mean (±SD)1.01 (±1.01)0.80 (±0.72)0.400.73 (±0.67)0.87 (±0.78)0.58
ct≥1, n (%)103/168 (61.3)36/56 (64.3)0.6916/26 (61.5)20/30 (66.7)0.69
ah, mean (±SD)0.85 (±0.99)1.04 (±1.11)0.321.08 (±1.06)1.00 (±1.17)0.61
ah≥1, n (%)88/168 (52.4)32/56 (57.1)0.5417/26 (65.4)15/30 (50.0.4)0.25
cv, mean (±SD)0.83 (±0.95)1.20 (±1.15)0.04a1.42 (±1.21)1.00 (±1.08)0.19
cv≥1, n (%)87/168 (51.8)35/56 (62.5)0.1618/26 (70.8)17/30 (56.7)0.33
TCMR, n (%)10/168 (6.0)14/56 (25.0)<0.001a8/26 (30.8)6/30 (20.0)0.35
Borderline, n (%)20/168 (11.9)6/56 (10.7)0.812/26 (7.7)4/30 (13.3)0.68
IFTA, n (%)80/168 (47.6)24/56 (42.9)0.5411/26 (42.3)13/30 (43.3)0.94
PVAN, n (%)2/168 (1.2)1/56 (1.8)>0.990/26 (0.0)1/30 (3.3)>0.99
ATN, n (%)34/168 (20.2)22/56 (39.3)0.004a9/26 (34.6)13/30 (43.3)0.51
GN, n (%)1/168 (0.6)3/56 (5.4)0.05a2/26 (7.7)1/30 (3.3)0.59
TMA, n (%)3/168 (1.8)6/56 (10.7)0.009a3/26 (11.5)3/30 (10.0)>0.99
Pyelonephritis, n (%)3/168 (1.8)0/56 (0.0)0.570/24 (0.0)0/30 (0.0)>0.99
  • Denominator numbers less than original group size indicate missing data. Percentage values may not add up to 100% due to rounding. g, glomerulitis; ptc, peritubular capillaritis; v, intimal arteritis; i, interstitial inflammation; t, tubulitis; ti, total inflammation; ci, interstitial fibrosis; ct, tubular atrophy; ah, arteriolar hyalinosis; cv, vascular fibrous intimal thickening; IFTA, interstitial fibrosis and tubular atrophy; PVAN, polyomavirus-associated nephropathy; ATN, acute tubular necrosis; TMA, thrombotic microangiopathy.

  • a Indicates significance P values for difference between groups.