Variable | Prematching | Postmatching^{a} | ||||
---|---|---|---|---|---|---|

CYC n=161 (64.1%) | RTX n=64 (25.5%) | P value^{b} | CYC n=60 (37.3%) | RTX n=60 (93.8%) | P value^{b} | |

Outcomes | ||||||

Vasculitis activity, n (%) | ||||||

Remission | ||||||

6 mo | 105 (76.6) | 50 (83.3) | 0.291 | 45 (75.0) | 49 (81.7) | 0.375 |

Total | 124 (87.9) | 54 (87.1) | 0.866 | 53 (93.0) | 54 (91.5) | 0.769 |

Complete remission | ||||||

6 mo | 23 (17.7) | 19 (31.7) | 0.031 | 12 (25.0) | 18 (31.6) | 0.457 |

Total | 72 (54.5) | 38 (66.7) | 0.178 | 31 (54.4) | 37 (62.7) | 0.096 |

Renal remission | ||||||

6 mo | 110 (78.0) | 52 (83.9) | 0.338 | |||

Total | 125 (88.7) | 54 (87.1) | 0.752 | |||

Relapse | ||||||

Total | 52 (38.5) | 23 (40.4) | 0.812 | |||

Renal relapse | 26 (16.1) | 16 (25.0) | 0.135 | |||

Death | ||||||

24 mo | 13 (8.1) | 8 (12.5) | 0.303 | |||

Total | 47 (29.2) | 12 (18.8) | 0.108 | |||

Renal recovery, n (%) | ||||||

ESKD | ||||||

24 mo | 45 (28.0) | 10 (15.6) | 0.052 | |||

Total | 58 (36.0) | 11 (17.2) | 0.006 | |||

Dialysis (total) | 41 (25.5) | 4 (6.3) | 0.002 | |||

Renal function recovery after 6 mo to an eGFR>30 ml/min per 1.73 m^{2} | 47 (46.5) | 22 (51.2) | 0.611 | |||

Combined events of ESKD and/or death, n (%) | ||||||

18 mo | 48 (29.8) | 15 (23.4) | 0.336 | |||

24 mo | 50 (31.1) | 15 (23.4) | 0.255 | |||

Total | 84 (52.2) | 19 (29.7) | 0.002 | |||

Time to event, median (IQR) mo | ||||||

Remission | 3.8 (2.6–5.8) | 3.2 (2.0–4.9) | 0.025 | 3.7 (2.6–5.9) | 3.2 (1.9–4.9) | 0.042 |

Relapse | 23.2 (7.9–61.2) | 13.5 (10.9–16.3) | 0.189 | |||

Death | 47.0 (16.0–91.0) | 12.8 (0.25–73.3) | 0.146 | |||

ESKD | 2.3 (0.1–25.6) | 0.2 (0.0–3.6) | 0.510 | |||

Combined events | 8.4 (0.5–51.0) | 2.5 (0.2–44.2) | 0.231 | |||

Time of FU after renal involvement, median (IQR) yr | 5.1 (1.3–11.1) | 3.8 (1.3–6.3) | 0.035 | |||

Time of FU, median (IQR) yr | 6.2 (1.5–12.2) | 4.9 (2.2–8.1) | 0.140 |

Population follow-up: 6 mo, CYC:

*n*=137 versus RTX:*n*=57; 18 mo, CYC:*n*=120 versus RTX:*n*=51; 24 mo, CYC:*n*=112 versus RTX:*n*=49. IQR, interquartile range; FU, follow-up.↵a The pairs used for the variables comparison after matching were obtained by analyzing the outcome of remission at 6 mo. Therefore, the comparisons pertaining to other outcomes are not shown.

↵b

*P*value <0.05 is considered significant (Pearson chi-squared test for categoric variables,*t*test for continuous variables with normal distribution, and Mann–Whitney*U*test for continuous variables with skewed distribution).c “Total” refers to the number of occurrences during all follow-up time.