Table 4.

Outcomes of patients with AAV and active severe renal disease treated with CYC or RTX for remission-induction (n=225)

VariablePrematchingPostmatchinga
CYC n=161 (64.1%)RTX n=64 (25.5%)P valuebCYC n=60 (37.3%)RTX n=60 (93.8%)P valueb
Outcomes
Vasculitis activity, n (%)
 Remission
  6 mo105 (76.6)50 (83.3)0.29145 (75.0)49 (81.7)0.375
  Total124 (87.9)54 (87.1)0.86653 (93.0)54 (91.5)0.769
 Complete remission
  6 mo23 (17.7)19 (31.7)0.03112 (25.0)18 (31.6)0.457
  Total72 (54.5)38 (66.7)0.17831 (54.4)37 (62.7)0.096
 Renal remission
  6 mo110 (78.0)52 (83.9)0.338
  Total125 (88.7)54 (87.1)0.752
 Relapse
  Total52 (38.5)23 (40.4)0.812
  Renal relapse26 (16.1)16 (25.0)0.135
 Death
  24 mo13 (8.1)8 (12.5)0.303
  Total47 (29.2)12 (18.8)0.108
Renal recovery, n (%)
 ESKD
  24 mo45 (28.0)10 (15.6)0.052
  Total58 (36.0)11 (17.2)0.006
  Dialysis (total)41 (25.5)4 (6.3)0.002
 Renal function recovery after 6 mo to an eGFR>30 ml/min per 1.73 m247 (46.5)22 (51.2)0.611
Combined events of ESKD and/or death, n (%)
 18 mo48 (29.8)15 (23.4)0.336
 24 mo50 (31.1)15 (23.4)0.255
 Total84 (52.2)19 (29.7)0.002
Time to event, median (IQR) mo
 Remission3.8 (2.6–5.8)3.2 (2.0–4.9)0.0253.7 (2.6–5.9)3.2 (1.9–4.9)0.042
 Relapse23.2 (7.9–61.2)13.5 (10.9–16.3)0.189
 Death47.0 (16.0–91.0)12.8 (0.25–73.3)0.146
 ESKD2.3 (0.1–25.6)0.2 (0.0–3.6)0.510
 Combined events8.4 (0.5–51.0)2.5 (0.2–44.2)0.231
Time of FU after renal involvement, median (IQR) yr5.1 (1.3–11.1)3.8 (1.3–6.3)0.035
Time of FU, median (IQR) yr6.2 (1.5–12.2)4.9 (2.2–8.1)0.140
  • Population follow-up: 6 mo, CYC: n=137 versus RTX: n=57; 18 mo, CYC: n=120 versus RTX: n=51; 24 mo, CYC: n=112 versus RTX: n=49. IQR, interquartile range; FU, follow-up.

  • a The pairs used for the variables comparison after matching were obtained by analyzing the outcome of remission at 6 mo. Therefore, the comparisons pertaining to other outcomes are not shown.

  • b P value <0.05 is considered significant (Pearson chi-squared test for categoric variables, t test for continuous variables with normal distribution, and Mann–Whitney U test for continuous variables with skewed distribution).

  • c “Total” refers to the number of occurrences during all follow-up time.