Table 2.

Outcomes of patients with AAV with active severe renal disease

VariableActive Severe Renal Disease in AAV n=251
Outcomes
 Vasculitis, n (%)
  Remission
   6 mo168 (66.9)
   Totala198 (78.8)
   Time to remission, median (IQR) mo3.7 (2.5–5.5)
  Complete remission
   At 6 mo46 (18.3)
   Totala119 (47.4)
   Time to complete remission, median (IQR) mo11.9 (3.2–17.6)
  Renal remission
   At 6 mo177 (70.5)
   Totala199 (79.3)
  Relapse
   At 12 mo32 (12.7)
   Totala81 (32.3)
   Time to relapse, median (IQR) mo16.0 (8.5–50.0)
   Renal relapse46 (18.3)
 Death
  At 24 mo22 (8.8)
  Totala62 (24.7)
  Time to death, median (IQR) mo44.8 (11.5–87.8)
  Death AAV related, n (%)34 (13.5)
 Renal, n (%)
  ESKD
   At 24 mo59 (23.5)
   Totala78 (31.1)
   Time to ESKD, median (IQR) mo3.0 (0.1–29.5)
  Dialysis54 (21.5)
   Dialysis within 4 wk of renal involvement diagnosis38 (72.2)
   Recovery of renal function after dialysis, n (%)12 (22.2)
   Renal function recovery after 6 mo to an eGFR>30 ml/min per 1.73 m278 (31.1)
  Combined events of ESKD and/or death, n (%)
   At 18 mo66 (26.3)
   At 24 mo69 (27.5)
   Totala114 (45.4)
   Time to combined events, median (IQR) mo7.3 (0.5–54.0)
Time of FU after renal involvement, median (IQR) yr4.8 (1.4–10.0)
Time of FU, median (IQR) yr5.6 (1.9–11.5)
  • IQR, interquartile range; FU, follow-up.

  • a “Total” refers to the number of occurrences during all follow-up time.