Table 7.

Outcomes of patients with AAV and active severe renal disease according with the status of treatment with PLEX (n=251)

VariablePrematchingPostmatchinga
No PLEX n=200 (79.7%)PLEX n=51 (20.3%)P valuebNo PLEX n=45 (22.5%)PLEX n=45 (88.2%)P valueb
Outcomes
Vasculitis activity, n (%)
 Remission
  6 mo132 (78.1)36 (73.5)0.497
  Totalc155 (88.6)43 (87.8)0.875
 Complete remission
  6 mo35 (21.7)11 (23.9)0.754
  Totalc91 (52.0)28 (57.1)0.516
 Renal remission
  6 mo139 (79.4)38 (77.6)0.775
  Totalc155 (88.6)44 (89.8)0.810
 Relapse
  12 mo25 (13.1)7 (14.9)0.745
  Totalc62 (37.8)19 (38.8)0.902
  Renal relapse36 (59.0)10 (52.6)0.623
 Death
  24 mo18 (9.0)4 (7.8)0.794
  Totalc45 (22.5)17 (33.3)0.109
Renal recovery, n (%)
 ESKD
  24 mo42 (21.0)17 (33.3)0.064
  Totalc57 (28.5)21 (41.2)0.081
  Dialysis (total)34 (17.0)20 (39.3)<0.00017 (15.5)16 (35.5)0.087
  Renal function recovery after 6 mo to an eGFR>30 ml/min per 1.73 m261 (50.0)17 (44.7)0.571
Combined events of ESKD and/or death, n (%)
 18 mo49 (24.5)18 (35.3)0.12015 (33.3)15 (33.3)0.99
 24 mo51 (25.5)18 (35.3)0.16216 (35.6)15 (33.3)0.824
 Totalc85 (42.5)29 (56.9)0.06624 (53.3)25 (55.6)0.832
Time to event, median (IQR) mo
 Remission3.7 (2.6–5.4)3.5 (2.4–6.0)0.926
 Relapse16.3 (9.7–37.1)23.8 (9.6–108.5)0.372
 Death39 (11.3–112.5)51 (6.0–71.5)0.658
 ESKD3.4 (0.2–33.1)1.8 (0.0–14.7)0.795
 Combined events10.9 (0.7–58.6)21.8 (0.1–50.8)0.6675.4 (0.26–38.5)6.6 (0.45–55.0)0.756
Time of FU after renal involvement, median (IQR) yr4.6 (1.2–10.5)5.0 (3.2–7.6)0.707
Time of FU, median (IQR) yr5.5 (1.4–11.4)6.6 (3.5–12.1)0.352
  • Population follow-up: 6 mo, no PLEX: n=172 versus PLEX: n=45; 12 mo, no PLEX: n=157 versus PLEX: n=45; 18 mo, no PLEX: n=147 versus PLEX: n=43; 24 mo, no PLEX: n=142 versus PLEX: n=39. IQR, interquartile range; FU, follow-up.

  • a The pairs resultant from the PS matching were obtained by the analysis of the outcome of combined events of ESKD and/or death at 18 mo. Therefore, the comparisons pertaining to other outcomes are not shown.

  • b P value <0.05 is considered significant (Pearson chi-squared test for categoric variables, t test for continuous variables with normal distribution, and Mann–Whitney U test for continuous variables with skewed distribution).

  • c “Total” refers to the number of occurrences during all follow-up time.