Table 3.

Factors assessed at time of post-transplant risk evaluation associated with COVID-19 disease in patients with kidney transplants: univariate and multivariate analysis

Factors Associated with COVID-19 Disease in Kidney Transplant PatientsNo. of PatientsNo. of COVID-19–Positive PatientsOdds Ratio (95% CI)P Value
Factors associated with COVID-19 disease: univariate analysis
 Recipient characteristics
  Age, per 1-yr increment1216661.01 (1.00 to 1.04)0.15
   Men777370.71 (0.43 to 1.17)0.17
   Non-White222242.75 (1.63 to 4.64)<0.001
 Transplant characteristics
  Donor type
   Deceased donor1053641
   Living donor16320.19 (0.05 to 0.79)<0.001
  Prior kidney transplant
   Yes13280.88 (0.41 to 1.88)0.69
  Time on dialysis before graft per 1-mo increment1078661.00 (1.00 to 1.01)0.09
  Multiorgan recipient
   Yes9641.35 (0.48 to 3.79)0.57
 Time of risk evaluation
 Time from transplant to evaluation per 1-mo increment1216660.99 (0.99 to 1.00)0.02
 Functional allograft parameters
  Recent episode of rejection
   Yes245120.87 (0.46 to 1.66)0.68
  Serum creatinine per μmol/L increment1185661.00 (1.00 to 1.01)0.11
   Yes15660.67 (0.28 to 1.57)0.35
  Obesity (BMI≥30)
   Yes151203.31 (1.90 to 5.77)<0.001
   Yes290313.05 (1.84 to 5.04)<0.001
   Yes929582.32 (1.10 to 4.92)0.02
  Asthma and chronic pulmonary disease
   Yes78134.09 (2.12 to 7.89)<0.001
  Cardiovascular disease
   Yes7010.24 (0.03 to 1.76)0.17
 Maintenance immunosuppressive therapies
   Yes829552.31 (1.19 to 4.46)0.01
   Yes691370.94 (0.57 to 1.55)0.80
   Yes360201.02 (0.59 to 1.74)0.95
  Mycophenolate mofetil or mycophenolic acid
   Yes996530.81 (0.43 to 1.52)0.51
   No (CNI regimen)a1051570.61 (0.25 to 1.47)0.28
   Yes15080.96 (0.45 to 2.05)0.92
Factors associated with COVID-19 disease: multivariate model
  Yes741551.67 (0.87 to 3.47)0.15
  Non-White205242.17 (1.23 to 3.78)0.007
 Cardiovascular disease
  Yes6410.20 (0.03 to 1.50)0.12
 Obesity (BMI≥30)
  Yes134202.19 (1.19 to 4.05)0.01
 Asthma and chronic pulmonary disease
  Yes70133.09 (1.49 to 6.41)0.002
  Yes249313.33 (1.92 to 5.77)<0.001
 Time on dialysis before graft per 1-mo increment1034661.01 (0.99 to 1.01)0.07
  • OR, odds ratio; BMI, body mass index; CNI, calcineurin inhibitor (cyclosporin or tacrolimus).

  • a Three patients did not take either CNI or belatacept.

  • b The multivariable analysis was restricted to 1034 patients without any missing data for each of the variables included in the final model by the stepwise backward elimination.