Table 1.

Baseline characteristics of adult patients with MCNS in each treatment group (modified ITT)

Patient CharacteristicsTacrolimus and Low-Dose Steroid (n=67)High-Dose Steroid (n=69)
Sex, men, n (%)45 (67.2)40 (58.0)
Age, yr41.8±16.742.2±17.8
 Median (min, max)40 (18, 78)39 (16, 79)
 (95% CI)(37.7 to 45.9)(37.9 to 46.5)
Weight, kg68.9±13.964.4±13.0
 Median (min, max)67 (47, 129.8)63.2 (42, 115)
  (95% CI)(65.5 to 72.2)(61.3 to 67.5)
BP, mm Hg
 Systolic122.2±14.4121.5±13.2
  Median (min, max)122 (96, 168)120.5 (99, 183)
  (95% CI)(118.7 to 125.7)(118.3 to 124.7)
 Diastolic76.1±9.075.8±9.9
  Median (min, max)75 (58, 97)75 (58, 122)
  (95% CI)(73.9 to 78.3)(73.4 to 78.2)
Serum albumin, g/dl2.3±0.72.4±0.8
 Median (min, max)2.2 (1.1, 4.0)2.3 (0.9, 4.1)
 (95% CI)(2.2 to 2.5)(2.3 to 2.6)
Creatinine, mg/dl0.9±0.30.9±0.4
 Median (min, max)0.84 (0.45, 1.8)0.82 (0.34, 2.4)
 (95% CI)(0.8 to 1.0)(0.8 to 1.0)
MDRD eGFR, ml/min per 1.73 m2a95.9±33.797.6±39.6
 Median (min, max)90.2 (34.6, 216.6)93.3 (34.0, 240.8)
 (95% CI)(87.7 to 104.1)(88.1 to 107.2)
UPCR, g protein/g creatinine8.4±3.99.2±6.5
 Median (min, max)7.58 (3.3, 20.0)7.8 (1.1, 34.8)
 (95% CI)(7.4 to 9.3)(7.6 to 10.7)
Blood glucose, mg/dl100.9±22.0100.8±16.2
 Median (min, max)96 (77, 203)99 (65, 152)
 (95% CI)(95.6 to 106.3)(96.9 to 104.7)
LDL cholesterol, mg/dl243.9±117.8217.7±102.7
 Median (min, max)235.5 (27.0, 524.0)195 (72.2, 531.0)
 (95% CI)(214.5 to 273.4)(192.3 to 243.1)
MCNS first presentation/relapse, n32/3536/33
  • Values expressed as mean ± SD, unless stated otherwise. MDRD eGFR, Modification of Diet in Renal Disease estimated glomerular filtration rate.

  • a Four patients had an eGFR <45 ml/min per 1.73 m2 at baseline, and eGFR improved by Week 8 in three of these patients (follow-up data missing for the fourth patient).