Table 7.

Multivariable analysis of predictive factors for ESKD at 10 years

FactorsUnivariable Cox RegressionMultivariable Cox Regression
HR (95% CI)P ValueaHR (95% CI)P Valuea
Combined class 5 LMN with or without class 3/4 LN
 Age0.97 (0.94 to 1.01)0.21
 Male2.82 (1.12 to 7.08)0.032.92 (1.16 to 7.34)0.02
 EXT1/EXT2-negative5.85 (1.36 to 25.24)0.02
 SCr at presentation1.36 (1.10 to 1.69)0.004
 Proteinuria at presentation0.96 (0.83 to 1.11)0.58
 Hematuria1.15 (0.66 to 1.98)0.63
 Other autoimmune diseases1.08 (0.39 to 2.97)0.88
 ≥25% glomerulosclerosis3.93 (1.63 to 9.47)0.0024.03 (1.67 to 19.71)0.002
 ≥25% IFTA4.23 (1.74 to 10.28)0.001
Only class 5 LMN (without class 3/4 LN)
 Age0.99 (0.95 to 1.04)0.67
 Male2.35 (0.72 to 7.70)0.16
 EXT1/EXT2-negative3.56 (0.79 to 16.08)0.1
 SCr at presentation1.27 (0.9 to 1.81)0.18
 Proteinuria at presentation1.02 (0.91 to 1.15)0.77
 Hematuria1.40 (0.66 to 2.99)0.38
 Other autoimmune diseases1.29 (0.4 to 4.18)0.68
 ≥25% glomerulosclerosis4.31 (1.44 to 12.88)0.009
 ≥25% IFTA3.91 (1.31 to 11.73)0.02
Class 5 LMN with class 3/4 LN
 Age0.93 (0.84 to 1.04)0.20
 Male6.33 (1.03 to 38.8)0.058.35 (1.11 to 62.60)0.04
 EXT1/EXT2-negative
 SCr at presentation1.40 (1.02 to 1.92)0.041.53 (1.04 to 2.25)0.03
 Proteinuria at presentation0.21 (0.02 to 3.04)0.25
 Hematuria0.73 (0.30 to 1.75)0.48
 Other autoimmune diseases0.85 (0.1 to 7.50)0.88
 ≥25% glomerulosclerosis2.52 (0.55 to 11.50)2.52
 ≥25% IFTA6.36 (1.27 to 31.80)0.02
  • a P<0.05 is considered significant.