Table 1.

Clinicopathologic features of EXT1/EXT2-positive and EXT1/EXT2-negative LMN

VariableEXT1/EXT2-Positive, n=122EXT1/EXT2-Negative, n=252P Valuea
Age, yrMedian: 32Median: 350.01
IQR: 25–41IQR: 27–45
SexMale: 16 (13.1%)Male: 47 (18.7%)0.18
Female: 106 (86.9%)Female: 205 (81.3%)
SCr at presentation, mg/dlMedian: 0.8Median: 0.90.02
IQR: 0.6–1.2; n=112IQR: 0.7–1.4; n=227
Proteinuria at presentation, g/24 hMedian: 3.5Median: 30.08
IQR: 2–6.6; n=95IQR: 1.8–4.8; n=199
Proteinuria ≥3.5 g/d at presentation57 (60%); n=9587 (43.7%); n=1990.009
Hematuria41 (33.6%)87 (34.5%)0.86
Other autoimmune disease32 (26.2%)47 (18.7%)0.09
Sclerosed glomeruli, %Median: 3.8Median: 9.10.001
IQR: 0–12.1IQR: 0–24.8
IFTA, %Median: 0Median: 10<0.001
IQR: 0–10IQR: 5–20
Proliferative features on light microscopy30 (24. 6%)81 (32.1%)0.13
Immunofluorescence (glomerular staining)Total cases with immunofluorescence (n=118)Total cases with immunofluorescence (n=244)
IgG: 2–3+ (n=118, 100%)IgG (n=244, 100%):
IgA (n=89, 75.4%);trace (n=3);
trace (n=17);1+ (n=8);
1+ (n=22);2–3+ (233)
2–3+ (50)IgA (n=186, 76.2%):
IgM (n=103, 87.3%):trace (n=35);
trace (n=23);1+ (n=53);
1+ (n=32);2–3+ (98)
2–3+ (48)IgM (n=220, 90.2%):
C1q (n=107, 90.7%):trace (n=27);
trace (n=18);1+ (n=75);
1+ (n=20);2–3+ (118)
2–3+ (69)C1q (n=216, 88.5%):
C3 (n=117, 99.2%):trace (n=38);
trace (n=2);1+ (n=39);
1+ (n=6);2–3+ (139)
2–3+ (109)C3 (n=238, 97.5%):
κ light chain (n=118, 100%):trace (n=11);
trace (n=3);1+ (n=29);
1+ (n=8);2–3+ (198)
2–3+ (107)κ light chain (n=241, 98.8%):
λ light chain (n=118, 100%):trace (n=12);
trace (n=1);1+ (n=31);
1+ (n=1);2–3+ (198)
2–3+ (116)λ light chain (n=241, 98.8%):
trace (n=10);
1+ (n=22);
2–3+ (209)
Electron microscopySubepithelial deposits: 122 (100%), of which 62 (50.8%) also had intramembranous depositsSubepithelial deposits: 250 (99.2%), of which 153 (61.2%) also had intramembranous deposits
Mesangial/paramesangial deposits: 116 (95.1%)Intramembranous deposits only: 2 (0.8%)
Subendothelial deposits: 71 (58.2%)Mesangial/paramesangial deposits: 239 (94.8%)
Tubuloreticular inclusions: 107 (87.7%)Subendothelial deposits: 146 (57.9%)
Tubuloreticular inclusions: 199 (79.0%)
  • a P<0.05 is considered significant.