Table 4.

Univariate and multivariable analysis by logistic regression on factors associated with primary endpoint (a composite endpoint of admission to intensive care unit, use of invasive mechanical ventilation, and death) in patients infected by SARS-CoV and SARS-CoV-2

ParametersSARS-CoV (n=1565)aSARS-CoV-2 (n=814)
Univariate AnalysisMultivariable AnalysisbUnivariate AnalysisMultivariable Analysisc,d
OR (95% CI)P valueaOR (95% CI)P valueOR (95% CI)P valueaOR (95% CI)P value
Age1.04 (1.03 to 1.04)<0.0011.02 (1.01 to 1.03)<0.0011.05 (1.03 to 1.07)<0.0011.02 (1.00 to 1.04)0.05
Male sex1.76 (1.40 to 2.21)<0.0011.76 (0.99 to 3.12)0.06
Diabetes mellitus4.89 (3.70 to 6.46)<0.0012.67 (1.93 to 3.69)<0.00111.33 (6.21 to 20.66)<0.0014.77 (2.32 to 9.84)<0.001
Hypertension4.24 (3.27 to 5.49)<0.0011.65 (1.17 to 2.33)0.0056.01 (3.41 to 10.59)<0.001
Lymphocyte <1×109/L1.10 (0.87 to 1.38)0.432.90 (1.67 to 5.04)<0.0011.93 (1.01 to 3.69)0.048
Platelet <100×109/L1.29 (0.80 to 2.09)0.293.49 (0.38 to 31.78)0.27
Peak ALT and/or AST ≥80 U/L1.72 (1.37 to 2.16)<0.0012.47 (1.87 to 3.25)<0.00110.59 (5.76 to 19.49)<0.0017.64 (3.99 to 14.64)<0.001
AKI defined by KDIGO9.26 (6.72 to 12.76)<0.0014.96 (3.48 to 7.06)<0.0014.64 (2.38 to 9.06)<0.0012.44 (1.06 to 5.58)0.04
  • a Twenty patients who received RRT at diagnosis of SARS-CoV were not included in the analysis.

  • b P value = 0.20 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit.

  • c P value = 0.77 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit.

  • d Age was retained in the model on the basis of the result of backward stepwise selection by likelihood ratio test with a P value of 0.05.