Table 3.

AKI in the first 30 d among patients infected by SARS-CoV and SARS-CoV-2 with or without the study outcomes

Occurrence of AKIWithout Primary EndpointWith Primary Endpoint
SARS-CoV, n=1148SARS-CoV-2, n=759P valueSARS-CoV, n=417SARS-CoV-2, n=55P value
Peak creatinine level median (range)83 (73–96)81 (68–95)0.001101 (81–177)89 (76–119)0.06
 No AKI, n (%)1083 (94.3)707 (93.1)0.04268 (64.3)41 (74.5)0.07
 AKI stage 1, n (%)55 (4.8)49 (6.5)68 (16.3)5 (9.1)
 AKI stage 2, n (%)3 (0.3)3 (0.4)30 (7.2)0 (0)
 AKI stage 3, n (%)7 (0.6)0 (0)51 (12.2)9 (16.4)
Without ICU admissionWith ICU admission
SARS-CoV, n=1240SARS-CoV-2, n=761P valueSARS-CoV, n=325SARS-CoV-2, n=53P value
Peak creatinine level median (range)84 (73–99)81 (68–95)<0.00197 (80–144)88 (75–118)0.12
 No AKI, n (%)1128 (91.0)708 (93.0)0.003223 (68.6)40 (75.5)0.11
 AKI stage 1, n (%)82 (6.6)50 (6.6)41 (12.6)4 (7.5)
 AKI stage 2, n (%)10 (0.8)3 (0.4)23 (7.1)0 (0)
 AKI stage 3, n (%)20 (1.6)0 (0)38 (11.7)9 (17.0)
Without invasive mechanical ventilationWith invasive mechanical ventilation
SARS-CoV, n=1504SARS-CoV-2, n=792P valueSARS-CoV, n=61SARS-CoV-2, n=22P value
Peak creatinine level median (range)86 (74–102)81 (68–95)<0.001109 (87–181)88 (77–315)0.24
 No AKI, n (%)1319 (87.7)734 (92.7)<0.00132 (52.5)14 (63.6)0.41
 AKI stage 1, n (%)112 (7.4)51 (6.4)11 (18.0)3 (13.6)
 AKI stage 2, n (%)26 (1.7)3 (0.4)7 (11.5)0 (0)
 AKI stage 3, n (%)47 (3.1)4 (0.5)11 (18.0)5 (22.7)
SurvivalDeath
SARS-CoV, n=1398SARS-CoV-2, n=810P valueSARS-CoV, n=167SARS-CoV-2, n=4P value
Peak creatinine level median (range)84 (73–98)81 (68–95)<0.001161 (104–289)332 (117–595)0.31
 No AKI, n (%)1290 (92.3)747 (92.2)0.2761 (36.5)1 (25.0)0.81
 AKI stage 1, n (%)77 (5.5)53 (6.5)46 (27.5)1 (25.0)
 AKI stage 2, n (%)13 (0.9)3 (0.4)20 (12.0)0 (0)
 AKI stage 3, n (%)18 (1.3)7 (0.9)40 (24.0)2 (50.0)
  • A total of 20 patients who received RRT at diagnosis of SARS-CoV were not included in the analysis.

  • Primary endpoint was a composite endpoint of ICU admission, use of invasive mechanical ventilation, and/or death. Baseline creatinine level was on the basis of the creatinine level before or upon hospital admission. Peak creatinine level was presented in median (range). Qualitative and quantitative differences between subgroups were analyzed by chi-squared or Fisher’s exact tests for categorical parameters and Mann–Whitney U test for continuous parameters, as appropriate.