Table 1.

Demographic, clinical, and histologic characteristics of the patients and biopsies included

Cohort CharacteristicsTotal (n=936)
Donor demographics
 Donor type, N (%)
  Donation after brain death726 (77.6)
  Donation after cardiac death153 (16.3)
 Living donation, N (%)57 (6.1)
 Age (yr), mean±SD47.7±14.7
 Male, N (%)497 (53.1)
 Diabetes, N (%)24 (2.6)
Recipient demographics
 Age (yr), mean±SD53.5±13.3
 Male, N (%)572 (61.1)
 Ethnicity, N (%)
  Caucasian920 (92.3)
  African12 (1.3)
  Asian3 (0.3)
  Hispanic1 (0.1)
 BMI (kg/m2), mean (range)25.4 (4.5)
 Pre-transplant donor-specific HLA antibodies, N (%)408 (11.6%)
Repeat transplantation, N (%)141 (15)
Cold ischemia time (h), mean±SD14.2±5.7
Total number of HLA A/B/DR mismatches, mean±SD2.8 (1.3)
Biopsy characteristicsTotal (n=3510)
Banff 2019 diagnosis, N (%)
 No rejection2671 (76.1)
 Borderline changes333 (9.5)
 TCMR314 (8.9)
 ABMR110 (3.1)
 Mixed rejection (ABMR + TCMR)61 (1.7)
 Mixed borderline rejection (ABMR + borderline changes)21 (0.6)
Indication biopsies, N (%)n=773 (22.0)
 Days since transplantation, median (interquartile range)22 (8–96)
 eGFR at d of biopsy, median (interquartile range)19.8 (10.9–29.0)
Protocol biopsies, N (%)n=2737 (78.0)
 3 mo823 (30.1)
 12 mo759 (27.7)
 24 mo639 (23.3)
 36 mo205 (7.5)
 48 mo22 (0.8)
 60 mo289 (7.6)
 Days since transplant, median (interquartile range)377 (100–752)
 eGFR at d of biopsy, median (interquartile range)46.4 (36.5–57.8)