Table 1.

Comparison of intravenous pharmacokinetic parameters for NESP and Epoetin alfaa

ParameterNESP (n = 11)Epoetin (n = 10)
aResults are given as mean ± SEM. NESP, novel erythropoiesis stimulating protein; t1/2,z, terminal half-life; CL, clearance; AUC, area under the serum concentration-time curve; Vd, volume of distribution at steady state.
t1/2,z (hours)25.3 ± 2.28.5 ± 2.4
CL (ml/h per kg)1.6 ± 0.34.0 ± 0.3
AUC(0-96) (ng · h per ml)291.0 ± 7.6131.9 ± 8.3
Vd (ml/kg)52.4 ± 2.048.7 ± 2.1