Table 1.

Assignment of patients to diet and blood pressure groups in Studies A and Ba

Mean Arterial Pressurec
DietbStudy A (n = 585)Study B (n = 255)
UsualLowUsualLow
Reprinted with permission from N Engl J Med (1).
aPatients in Study A had a GFR of 25 to 55 ml/min per 1.73 m2 (mean [SD] serum creatinine 1.9 [0.5] mg/dl); patients in Study B had a GFR of 13 to 24 ml/min per 1.73 m2 (mean [SD] serum creatinine 3.4 [0.9] mg/dl).
bThe usual protein diet consisted of 1.3 g of protein and 16 to 20 mg of phosphorus per kilogram (standard body weight) per day; the low protein diet consisted of 0.58 g of protein (≥0.35 g of protein high in essential amino acids) and 5 to 10 mg of phosphorus per kilogram per day; the very low protein diet consisted of 0.28 g of protein and 4 to 9 mg of phosphorus per kilogram per day, supplemented by a ketoacid-amino acid mixture (0.28 g/kg per d) (Ross Laboratories, Columbus, OH).
cThe usual mean arterial pressure was ≤107 mmHg for patients 18 to 60 yr old at entry (equivalent to 140/90 mmHg) or ≤113 mmHg for patients ≥61 yr old at entry (equivalent to 160/90 mmHg); low mean arterial pressure was ≤92 mmHg for patients 18 to 60 yr old at entry (equivalent to 125/75 mmHg) or ≤98 mmHg for patients ≥61 yr old at entry (equivalent to 145/75 mmHg).
Usual protein145149
Low protein1401516267
Very low protein6165