Table 3.

Adjusted association of GFR slope and relative risk of renal failure or death with total protein intake and diet group in Study Ba

ParameterEstimate (CI)P Value
aA 0.2 g/kg per d lower total protein intake was associated with a 1.15 ml/min per yr less steep mean GFR slope (29%) and a 51% relative risk of renal failure or death. Combining patients in both diet groups and controlling for baseline covariates associated with progression. Covariates included in both regression models included diagnosis of polycystic kidney disease, race, baseline levels of serum transferrin, high-density lipoprotein cholesterol, mean arterial pressure, and protein intake, as well as mean follow-up mean arterial pressure and its interaction with baseline proteinuria. Baseline GFR was also included in regression model for relative risk of renal failure or death.
GFR slope (ml/min per yr)
protein intake (0.2 g/kg per d lower)1.15 (0.27 to 2.03)0.011
assignment to supplemented very low protein diet-0.15 (-0.95 to 0.65)0.71
Relative risk of renal failure or death
protein intake (0.2 g/kg per d lower)0.51 (0.34 to 0.76)0.001
assignment to supplemented very low protein diet1.03 (0.70 to 1.51)0.87